Computational assessment of the binding interactions of drugs is an important component of computer-aided drug design paradigms. In this perspective, a set of 30 1-(substituted phenyl)-3-(naphtha[1, 2-d] thiazol-2-yl) urea/thiourea derivatives showing antiparkinsonian activity were docked into inhibitor binding cavity of human adenosine A(2A) receptor (AA2AR) to understand their mode of binding...

introduction. medical education curriculum improvements can be achieved by evaluating students’ performance. medical students have to pass two undergraduate comprehensive examinations, basic science and preinternship, in iran. to measure validity of the students’ mean score in comprehensive basic science exam (cbse) for predicting their performance in later curriculum phases. methods. this desc...

We propose a new technique for modifying the time-scale of speech using Independent Subspace Analysis (ISA). To carry out ISA, the single channel mixture signal is converted to a time-frequency representation such as spectrogram. Here, the spectrogram is generated by taking Hartley or Wavelet transform on overlapped frames of speech. We do dimensionality reduction of the autocorrelated original...

OBJECTIVES PD-1/PD-L1 and CTLA-4 have been investigated and are thought to play an important role in tumor evasion. This study aimed to investigate expression patterns of immune-related molecules, and their clinical impacts in malignant salivary gland tumors. PATIENTS AND METHODS We performed immunohistochemical staining for PD-L1, PD-L2, CTLA-4, PD-1, and CD8+ tumor-infiltrating lymphocytes ...

A reliability analysis of suspension bridges against buffeting failure due to gustiness of wind velocity is carried out using the concept of PRA (probabilistic risk analysis) procedure. For this purpose, the bending stresses at the critical nodes of the bridge deck are obtained for buffeting forces using a spectral analysis technique and a finite element approach. For the purpose of reliability...

The transition from the low Q2 region in deep inelastic scattering where charm production is described by photon-gluon fusion to a region where the charm structure function F c 2 is largely generated by a charm quark density should be a smooth passage. The all orders prescription for matching between the two schemes does not uniquely determine all the relevant coefficient functions (CF’s) or gu...