The biosynthesis of eukaryotic lipid-linked oligosaccharides (LLOs) that act as donor substrates in eukaryotic protein N-glycosylation starts on the cytoplasmic side of the endoplasmic reticulum and includes the sequential addition of five mannose units to dolichol-pyrophosphate-GlcNAc2. These reactions are catalyzed by the Alg1, Alg2 and Alg11 gene products and yield Dol-PP-GlcNAc2Man5, an LLO...

In the current study, we tested a hypothesis that CD36 fatty acid (FA) transporter might affect insulin sensitivity by indirect effects on FA composition of adipose tissue. We examined the effects of CD36 downregulation by RNA interference in 3T3-L1 adipocytes on FA transport and composition and on sensitivity to insulin action. Transfected 3T3-L1 adipocytes, without detectable CD36 protein, sh...

The ability of organisms to quickly respond to stresses requires the activation of many intracellular signal transduction pathways. The sphingolipid intermediate ceramide is thought to be particularly important for activating and coordinating signaling pathways during mammalian stress responses. Here we present the first evidence that ceramide and other sphingolipid intermediates are signaling ...

Gasoline motor is an internal combustion where the power used to drive obtained from of fuel that occurs inside itself, so gases occur simultaneously function as a working fluid. Advances in automotive technology, including high compression systems, require right type for complete combustion. This can be met by using C20 additives improve engine performance. study compares use pure gasoline wit...

Prasugrel, a thienopyridine antiplatelet drug, is converted in animals and humans to the pharmacologically active metabolite R-138727 [(2Z)-{1-[(1RS)-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]4-sulfanylpiperidin-3-ylidene}ethanoic acid], which has two chiral centers, occurring as a mixture of four isomers. The RS and RR isomers are more active than the SS and SR isomers (RS > RR > > SR = SS)....

S U M M A R Y In this study, we develop a methodology to estimate monthly variations in degree-1 and C20 coefficients by combing Gravity Recovery and Climate Experiment (GRACE) data with oceanicmass anomalies (combination approach).With respect to themethod by Swenson et al., the proposed approach exploits noise covariance information of both input data sets and thus produces stochastically opt...

The lipid composition of arterial walls changes during development, ageing and pathological processes. Preeclampsia is the most common pregnancy-associated pathological syndrome. It is accompanied by significant remodelling of extracellular matrix both in the umbilical cord vessels and in the surrounding Wharton’s jelly. The lipids of the umbilical cord were not studied till now, therefore it w...