liquiritigenin is a chiral flavonoid present in plant based food, nutraceuticals, and traditional medicines. it is also an important ingredient present in licorice. the purpose of this study is to explore the pharmacological activity of racemic liquiritigenin utilizing several in vitro assays with relevant roles in colon cancer and diabetes. where possible, the pure enantiomers were tested to i...

in the human genome, chromosome 11 contains a cluster of matrix metalloproteinase (mmp) genes. single nucleotide polymorphisms in the promoter region of mmp genes are important for mmp expression. a common adenine deletion polymorphism (5a) at position -1171 of the mmp-3 gene promoter (5´-aaaaaaccat-3´ change to 5´-aaaaaccat-3´) facilitates transcriptional factor binding and mmp-3 promoter acti...

Background The impact of cancer therapy on the reproductive potential of patients is increasingly recognized because survival rates of patients have clearly improved in recent years. The study stressed the use of AMH may allow better prediction of chemotherapy-related risk to further fertility. MaterialsAndMethods A narrative review was performed within articles published at PubMed, Elsevier, S...

Compounds containing triazene ring structure are cytotoxic agents and clinically used as antitumor alkylating agents. In this study, a series of triazene derivatives holding alkyl and aryl moieties were synthesized and proved to be potent cytotoxic agents in-vitro particularly against eight cancer cell lines (PC3, HT29, Hela, HL60, Jurkat, K562, MCF7, HepG2) and a non-cancerous cell line (HUVEC...

a series of 2-amino-4-(nitroalkyl)-4h-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using dbu (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. the cytotoxic activity of target compounds were evaluated against t...

Four prenylated flavonoids including isosophoranone, sophoraflavanone G, alopecurone J, alopecurone P and a resveratrol derivative HPD (2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b] furan-3,4,6-triol), were isolated from the roots of Sophora pachycarpa. The cytotoxic activity of obtained compounds was evaluated against A2780, A549, HeLa, and HCT116 human cancer cell lines. We also evaluated their his...

A new series of 1,2-diaryl-4,5,6,7-tetrahydro-1H-benzo[d]imidazoles, possessing trimethoxy phenyl pharmacophore, were synthesized to evaluate their biological activities as tubulin inhibitors. Cytotoxic activity of the synthesized compounds 7a-f was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HEPG2 (liver hepatocellular cells), A549 (adenocarcinomic h...