Abstract Many drugs have been developed for anticancer chemotherapy. However, more anti-cancer should be from potential chemicals to circumvent the disadvantages of existing drugs. Most induce apoptosis in cancer cells. This study tested efficiency a new chemical, piperazine derivative 1-[2-(Allylthio) benzoyl]-4-(4-methoxyphenyl) (CB01), on glioblastoma (U87) and cervix (HeLa) CB01 was highly ...

Sepsis is an imbalanced response to infection that leads life-threatening organ dysfunction. Although increasing number of anti-inflammatory drugs are available, the options for treating sepsis remain limited. Therefore, it imperative understand pathogenesis and pathophysiology develop novel therapeutic targets treat this state. The Nod-like receptor family pyrin domain-containing 3 (NLRP3) inf...

background: our previous studies revealed an inhibitory effect of icd-85 (venom derived peptides) on mda-mb231 and hl-60 cell lines, through induction of apoptosis. the purpose of this study was to investigate apoptosis-induced mechanism on hela and mrc-5 cells by icd-85 through activation of caspase-8. methods: cell viability, cytosolic enzyme lactate dehydrogenase (ldh) and cell morphology we...

Soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and anti-proliferative effects have been studied in different cancer cells. However, the mechanisms of action of genistein and its molecular targets on human colon cells have not been fully elucidated. Therefore, caspase-3 and p38 mitogen-activated protein kinase (p38 MAPK) as the main therapeutic targets...

delayed neuronal death after seizure attack may be mediated by the induction of apoptosis-pathway. caspase-3, a mammalian cysteine protease, promotes apoptosis after some neurological disorders. neuron regeneration peptides (nrps) are small synthetic peptides that stimulate neural proliferation, migration, and differentiation with no apparent toxicity and high target specificity in cns. in the ...