Some species mount a robust antibody response despite having limited genome-encoded combinatorial diversity potential. Cows are unusual in having exceptionally long CDR H3 loops and few V regions, but the mechanism for creating diversity is not understood. Deep sequencing reveals that ultralong CDR H3s contain a remarkable complexity of cysteines, suggesting that disulfide-bonded minidomains ma...

The bandwidth demands of modern computing systems have been continually increasing and the recent focus on parallel processing will only increase the demands placed on data communication circuits. As data rates enter the multi-Gb/s range, serial data communication architectures become attractive as compared to parallel architectures. Serial architectures have long been used in fibre optic syste...

The third complementary determining region of the immunoglobulin heavy chain (CDR H3) is one of the more difficult structures to model due to genetic reasons. However, the conformation of proximal to beta-framework ("torso") part of the CDR H3 is very predictable. Current "CDR's canonical classes" theory is based on identifying the key positions, H94 and H101. We can determine the CDR H3 "torso...

Tomato cell suspensions have been selected for sustained growth on normally lethal concentrations of CdCl2. In cadmium-resistant (CdR) cells, Cd2+ is found complexed with non-protein, cysteine-rich polypeptides which accumulate in high amounts when cells are grown in the presence of Cd2+. Sequence and linkage analysis of these peptides by triple quadrupole mass spectrometry establishes structur...

Building upon work of Y. Shalom we give a homological-algebra flavored definition of an induction map in group homology associated to a topological coupling. As an application we obtain that the cohomological dimension cdR over a commutative ring R satisfies the inequality cdR(Λ) ≤ cdR(Γ) if Λ embeds uniformly into Γ and cdR(Λ) < ∞ holds. Another consequence of our results is that the Hirsch ra...

Comorbid hyperammonemic encephalopathy (HE) and status epilepticus (SE) leading to extensive cortical diffusion restriction (CDR) on MRI have not been previously reported. We describe a patient with HE who subsequently developed provoked SE. Sequential MRIs demonstrated a progressive CDR that involved the entire bilateral supratentorial cortex, thalami, and basal ganglia, resulting in death fro...

DNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action. Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we demonstrate that low-dose 5-AZA-CdR targets colorectal cancer-initiating cells (CICs) by inducing viral mimicry. This is associated with induction of dsRNAs derived at least in part from endogenous ret...

The increasing availability of massive mobile phone call data records (CDR) has opened new opportunities for analyzing and understanding real-life social phenomena and human dynamics. In order to better interpret this enormous amount of data it is useful to contextualize them with information about the circumstances under which they has been generated. Nowadays, linked open data initiative prov...

In this letter, a 1.25-Gb/s 0.18-μm CMOS half-rate burstmode clock and data recovery (CDR) circuit is presented. The CDR contains a fast-locking clock recovery circuit (CRC) using a realigned oscillation technique to recover the desired clock. To reduce the power dissipation, the CRC uses a two-stage ring structure and a current-reused concept to merge with an edge detector. The recovered clock...

A subset of bovine antibodies have an exceptionally long third heavy-chain complementarity determining region (CDR H3) that is highly variable in sequence and includes multiple cysteines. These long CDR H3s (up to 69 residues) fold into a long stalk atop which sits a knob domain that is located far from the antibody surface. Three new bovine Fab crystal structures have been determined to deciph...