Peritonitis is frequently associated side effect of peritoneal dialysis of patients on continuous ambulatory peritoneal dialysis (CAPD).Clinical symptoms of CAPD include abdominal pain, tenderness, often rebound, and cloudy dialysate fluid. Common pathogens are 60% to 80% Staphylococcus epidermidis,Staphylococcus aureus, Streptococcus spp.Nasal carriage ofS.Aureus is associated with and increas...

 ABSTRACT Life-threatening infections caused by the encapsulated fungal pathogen Cryptococcus neoformans have been increasing steadily over the past 10 years. Cryptococcus neoformans is recognized as the most frequent fungal infection of the central nervous system (CNS) in immunocompetent as well as immunocompromised patients. We report the development of a semi-nested- PCR-based assay for the ...

intravitreal injection is the most common approach for drug delivery to the posterior segment in humans. however, following the injection, drugs are rapidly eliminated from the vitreous, with half-lives up to a few days. depending on the rate of clearance from the vitreous, large boluses and frequent administrations may be required to ensure therapeutic levels over an extended period of time. m...

objective (s): transdermal preparations for testosterone are becoming popular because of their unique advantages such as avoidance of first-pass effect, convenience, improved bioavailability, and reduction of systemic side effects. a novel testosterone transdermal delivery system (tdds) was developed using a palm oil base called hamintm (a commercial product) and tested using in vitro and in vi...

we describe a 40-year-old woman presenting with headache, nausea, episodic amnesia and blurred optic disc. brain mri disclosed diffuse leptomeningeal enhancement. csf analysis showed aseptic meningitis with elevated ace level. neurosarcoidosis was diagnosed based on granulomatosis changes on tissue biopsy.

background & objectives: the accurate assessment of the diseased tissue is fundamental to the diagnosis and management of disorders of the central nervous system (cns). the ‛squash’ or ‛crush’ technique has been universally employed in the intraoperative diagnosis of cns tumors. the aim of our study was to evaluate the accuracy of squash preparation in diagnosing cns tumors by comparing wit...

human infection with echinococcus granulosis is a common disease throughout south america, the mediterranean littoral, the middle east, central asia and east africa, which usually occur in children and young adults. formation of avascular cystic lesions in the liver, kidney, pancreas, bones, vitreus and brain can cause protean of signs and symptoms. intracranial cysts usually present with focal...

Present review highlights the potential of nasal mucosa as an administration route for targeting the central nervous system, the brain. Targeted drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of medication in the remaining tissues. Thus improving efficacy of the drug and reducing side effects. The nasal mucosa when compared...