نتایج جستجو برای: cervical cancer cells
تعداد نتایج: 2144225 فیلتر نتایج به سال:
Viral oncoproteins E6/E7 play key oncogenic role in human papillomavirus (HPV)-mediated cervical carcinogenesis in conjunction with aberrant activation of cellular signaling events. GLI-signaling has been implicated in metastasis and tumor recurrence of cervical cancer. However, the interaction of GLI-signaling with HPV oncogenes is unknown. We examined this relationship in established HPV-posi...
Flavonoids have been intensively explored for their anticancer activity. In this study, a total synthetic flavonoid protoapigenone, known as WYC02, was analysed for its potential anticancer activity on human cervical cancer cells as well as the underlying mechanisms for these effects. The site-moiety maps are used to explore the binding site similarity, pharmacophore and docking pose similarity...
Endometrial carcinoma is a malignancy originating from the epithelial cells lining uterine cavity. 1,3 Currently, endometrial often found in gynecological malignancies. sixth leading cause of death women. In Indonesia, cancer ranks third for genital after cervical (cervical) and ovarian cancer. An biopsy done to diagnose evaluate abnormal intrauterine bleeding, t. However, patients who cannot u...
The target protein for Xklp2 (TPX2), a microtubule-associated protein, can be used to evaluate more precisely the proliferative behavior of tumor cells. The abnormal expression of TPX2 in various types of malignant tumors has been reported, but less is known for cervical cancer. We studied the relationship between TPX2 expression and the biologica...
Background Cervical cancer is the fourth most common cancer among women worldwide. Organized cervical screening and vaccination against human papilloma virus (HPV) have been successful interventions for prevention of invasive cervical cancer (ICC). Because of cultural and religious considerations, ICC has low incidence in Iran and many other Muslim countries. There is no organized cervical scre...
OBJECTIVES Hemoglobin (Hgb) is the main oxygen and carbon dioxide carrier in cells of erythroid lineage and is responsible for oxygen delivery to the respiring tissues of the body. However, Hgb is also expressed in nonerythroid cells. In the present study, the expression of Hgb in human uterine cervix carcinoma cells and its role in cervical cancer were investigated. METHODOLOGY The expressio...
Tumor-associated macrophages (TAMs) are important components in tumor microenvironment. This study intended to explore the influence of TAMs on cervical cancer cells proliferation and migration. The expression levels markers, CD68 CD163, tissues were examined by immunohistochemistry increased with progression lesions (p < 0.05). M2-like phenotype (PMA(Polymethacrylate) induced THP-1 cells) noti...
S100A7 is an EF-hand calcium-binding protein that has been suggested to be implicated in cell proliferation, migration, invasion and tumor metastasis. However, its role in cervical cancer has not yet been fully clarified. The present study used immunohistochemistry analysis of S100A7 in clinical specimens of cervical cancer to show that S100A7 expression was significantly upregulated in cervica...
One of the most common types cancer in women is cervical cancer, a disease which prevalent poor nations, with one woman dying from it every two minutes. It has major impact on burden all cultures and economies. Clinicians have planned to use improvements digital imaging machine learning enhance screening recent years. Even while infections, generate positive tests, do not result precancer, who ...
Cisplatin (DDP)‑based chemotherapy is a standard treatment for cervical cancer, although resistance remains major concern. Hypoxia‑inducible factor‑2 α (HIF‑2α) plays an important role in resistance. MicroRNAs (miRs) can inhibit gene expression by binding to the 3'‑untranslated region of target gene. The authors' previous study showed that miR‑519d‑3p regulation HIF‑2α under hypoxic conditions ...
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