نتایج جستجو برای: chiral stability

تعداد نتایج: 336584  

2008
P. Papazoglou

We investigate the properties of different modifications to the linear σ-model (including a dilaton field associated with broken scale invariance) at finite baryon density ρ and nonzero temperature T . The explicit breaking of chiral symmetry and the way the vector meson mass is generated are significant for the appearance of a phase of nearly vanishing nucleon mass besides the solution describ...

Fu-Xue Chen, Pran Gopal Karmaker Qi Wang Shaoxiang Wu, Yao-Feng Wang

Trifluoromethylated organic compounds, especially chiral quaternary alcohols bearing trifluoromethyl group are of important intermediates in drugs, agrochemicals and etc.An efficient epoxidation of β-CF3-β,β-disubstituted unsaturated ketones (6) has been developed with environmental benign hydrogen peroxide as the oxidant and F5-substituted chiral qua...

Journal: :journal of sciences, islamic republic of iran 2015
m. j. taghizadeh f. salahi m. hamzelooian k. jadidi

an efficient, one-pot, four-component procedure for the synthesis of a small library of new chiral spiro- oxindolopyrrolidines with high regio-, diastereo- (>99:1 dr), and enantioselectivity (up to 80% ee) is described. in this process, the regio- and stereochemical 1,3-dipolar cycloaddition of azomethine ylides, which were generated insitu by the reaction of isatin derivatives and sarcosin,wit...

Journal: :Journal of medicinal chemistry 2009
François Maltais Young Chun Jung Minzhang Chen Jerry Tanoury Robert B Perni Nagraj Mani Leena Laitinen Hui Huang Shengkai Liao Hongying Gao Hong Tsao Eric Block Chien Ma Rebecca S Shawgo Christopher Town Christopher L Brummel David Howe S Pazhanisamy Scott Raybuck Mark Namchuk Youssef L Bennani

Telaprevir 2 (VX-950), an inhibitor of the hepatitis C virus (HCV(a)) NS3-4A protease, is in phase 3 clinical trials. One of the major metabolites of 2 is its P1-(R)-diastereoisomer, 3 (VRT-394), containing an inversion at the chiral center next to the alpha-ketoamide on exchange of a proton with solvent. Compound 3 is approximately 30-fold less active against HCV protease. In an attempt to sup...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Qing Chen Ting Chen Dong Wang Hui-Biao Liu Yu-Liang Li Li-Jun Wan

OPV3-CHO molecules are employed to prepare assembly on highly oriented pyrolytic graphite, and the so-prepared assembly is investigated by scanning tunneling microscopy. In the assembly chiral domains are observed with various structures such as linear and windmill. The chiral structural formation, stability, transition, and possible unification are intensively studied. After thermal annealing,...

2018
Ganapathy Subramanian Sankaran Srinivasan Arumugan Sivaraman Balasubramaniam

Over the last three decades, the sulfinyl group has received considerable attention in asymmetric synthesis1‒5 as a chiral tool. The sulfinyl group is widely used as to bring about numerous asymmetric transformations. The effectiveness of the sulfoxide in diastereoselective auxiliary-induced reactions is mainly due to the steric and stereo electronic differences existing between the substituent...

2008
Henrik Bohr João da Providência

We propose a QCD based many-body model for the nucleus where the strong coupling regime is controlled by a three body string force and the weak coupling regime is dominated by a pairing force. This model operates effectively with a quark-gluon Lagrangian containing a pairing force from instantons and a baryonic string term which contains a confining potential. The unified model for weak and str...

Journal: :Chemistry 2016
Lukas Trombach Sergio Rampino Lai-Sheng Wang Peter Schwerdtfeger

Golden fullerenes have recently been identified by photoelectron spectra by Bulusu et al. [S. Bulusu, X. Li, L.-S. Wang, X. C. Zeng, PNAS 2006, 103, 8326-8330]. These unique triangulations of a sphere are related to fullerene duals having exactly 12 vertices of degree five, and the icosahedral hollow gold cages previously postulated are related to the Goldberg-Coxeter transforms of C20 starting...

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