CV and usually in the first 12 h of life. Data Collection and Analysis: The methodological quality of each trial was independently reviewed by the various authors. The standard effect measures are relative risk (RR) and risk difference (RD). From 1/RD the number needed to treat to produce one outcome were calculated. For all measures of effect, 95% confidence intervals were used. In subgroup an...

Background and Aims: Interferon alpha is an effective cytokine in viral infections, where it has various roles in immune function. The use of this antiviral agent in the treatment of viral infections and even cancers is common, although, the beneficial effects of this antiviral agent in high doses can be associated with side effects that limit its use. In this project, we tried to investigate t...

Abstract Objectives The duration of administration (e.g., subchronic or chronic) haloperidol may influence its adverse effects. We studied the effects on body weight and fasting blood sugar (FBS). In addition, we examined whether orally administered cannabidiol (CBD) had any putative mitigating haloperidol-induced changes FBS elevation. Methods Haloperidol (5 mg/kg/day) was for 21 days (subchro...

background in patients with chronic hepatitis c, triple drug regimens containing a protease inhibitor, peginterferon and ribavirin were found to significantly increase sustained virologic response rates compared to dual drug regimen containing pegylated interferon and ribavirin, especially in genotype 1. objectives in turkey, telaprevir has been used since march 2013. we aimed to evaluate resul...

chronic lymphocytic leukemia (cll) and chronic myeloid leukemia (cml) are the most common leukemias of the elderly (>43 year). however, the sequential occurrence of cml followed by cll in the same patient is extremely rare. in our report, a 52-year-old female was diagnosed with cll (type of bone marrow (bm) infiltration was nodular and interstitial) and was treated with chlorambucil. 64 months ...

background: chronic obstructive pulmonary diseases (copd) are planned to rank fifth in burden of disease and third with respect to mortality by 2020. carrying out research regarding different aspects of copd is mentioned as important health priorities by academic institutions and governments. the burden of lung disease (bold) initiative was designed a decade ago to develop robust models that ca...

Functional safety standards (ISO 26262, IEC 61508) require a safety life cycle which demands additional design and engineering tasks to be managed. This paper addresses how the existing FMEAs have to be extended and refocused to address and overview signal paths throughout the system. The safety standards require to classify signals with a SIL (Safety Integrity Level) and the higher the SIL the...

Reaction times (rts) are an important source of information in experimental psychology. Classical methodological considerations pertaining to the statistical analysis of rt data are optimized for analyses of aggregated data, based on subject or item means (c.f., Forster & Dickinson, 1976). Mixedeffects modeling (see, e.g., Baayen, Davidson, & Bates, 2008) does not require prior aggregation and ...

Rank-Based methods for iid linear models have been developed over the past 30 years. However, little work has been done in the area of mixed models. In this paper, we discuss a transformation approach to modeling a particular mixed model: one with an arbitrary number of fixed effects and covariates but only one random effect. Discussion of the asymptotic theory is given and the results of a sim...