ABSTRACT Interview with Fernando Pigatto, President of National Health Council (CNS), carried out remotely, on 25/06/2021, when the country reached mark 500,000 deaths from COVID-19 pandemic. The interviewers aimed, through open questions, to collected information that would: i) present performance CNS in pandemic context, special its challenges and advances; ii) promote interviewee’s reflectio...

The major imperative of the pharmaceutical industry is to effectively translate insights gained from basic research into new medicines. This task is toughest for CNS disorders. Compared with non-CNS drugs, CNS drugs take longer to get to market and their attrition rate is greater. This is principally because of the complexity of the human brain (the cause of many brain disorders remains unknown...

Understanding how the brain works in tight concert with the rest of the central nervous system (CNS) hinges upon knowledge of coordinated activity patterns across the whole CNS. We present a method for measuring activity in an entire, non-transparent CNS with high spatiotemporal resolution. We combine a light-sheet microscope capable of simultaneous multi-view imaging at volumetric speeds 25-fo...

OBJECTIVES To describe the epidemiology and factors associated with pediatric central nervous system (CNS) tuberculosis (TB) in California from 1993 to 2011. METHODS We analyzed California TB registry data for persons aged ≤18 years, comparing CNS TB cases versus non-CNS TB cases reported from 1993 to 2011. Factors associated with CNS TB and TB deaths were identified by using multivariate log...

Introduction. Anosmia and ageusia are one of the most common characteristic symptoms severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection, with a frequency almost 50% in patients Western countries. Hypotheses proposing that virus potentially affects central nervous system (CNS) on rise. One hypothesis suggests enters via nasal mucosa then olfactory bulb cribriform plate, furth...

The development of Li-CO2/O2 battery with high energy density and long-term stability is urgently needed to fulfill the carbon neutralization pollution-free environment targets. biomass-derived heteroatom-doped catalyst combination high-efficiency catalytic activity sustainable supply a promising cathode in battery. Specifically, unique morphology mesopore structure can promote transfer CO2, O2...

Blood–brain barrier (BBB) permeability is an essential phenomena when considering the treatment of neurological disorders as well in case central nervous system (CNS) adverse effects caused by peripherally acting drugs. The presented work contains statistical analyses and correlation assessment analyzed group active pharmaceutical ingredients (APIs) with their BBB-permeability data collected fr...

Central neurocytoma (CN) is a rare and elusive tumor. The relationship between clinical outcome, tumor nature, treatment of CN remains controversial. There were eight patients in our hospital from 2014 to 2021, the prevalence accounted for 0.36% brain tumors. All them underwent surgical removal, two combined with adjuvant radiotherapy (RT). We found that four without complications had small tum...

Microglia is a type of glial cell located throughout the central nervous system (CNS), which is sensitive to CNS injury and disease. Responsibility of microglia as the resident macrophage cells for injuries suggests that these cells have the potential to act as diagnostic markers of disease beginning or progression. Function of Microglia is strongly synchronized by the microenvironment of brain...