1,3-Dibromo-5,5-dimethylhydantoin (DBH), as a cheap and commercially available reagent, is efficiently able to catalyze the synthesis of polyhydroquinoline derivatives and 12-aryl-8,9,10,12-tetrahydro[a] xanthene-11-ones via one-pot multi-component reactions. This novel synthetic method has the advantages of low cost and availability of the catalyst, short reaction times, high to excellent yiel...

The catalytic ability of ZrO(2)/SO(4)(2-) to promote solventless three-component condensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethyl acetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multi-component reactions are obtained in the presence of solid acid catalysts using the same reactants but different temperature conditions. The sulfat...

The Multi-sensor Cloud Retrieval Simulator (MCRS) produces a “simulated radiance” product from any high-resolution general circulation model with interactive aerosol as if a specific sensor such as the Moderate Resolution Imaging Spectroradiometer (MODIS) were viewing a combination of the atmospheric column and land–ocean surface at a specific location. Previously the MCRS code only included co...

offers many advantages as newly designed drugs. The benefits include enhanced stability to proteolytic enzymes, better transport through cellular membranes, increased bio-availability, changing agonist to antagonists potency and higher affinity in ligand-receptors interactions. D-amino acids are used to design and obtain new peptidomimetics by their incorporation in place of the natural L-amino...

Title: THE USE OF LATIN TERMINOLOGY IN MEDICAL CASE REPORTS: QUANTITATIVE, STRUCTURAL AND THEMATIC ANALYSIS Authors: Yuliia Lysanets ([email protected]) Olena Bieliaieva ([email protected]) Version: 1 Date: 29 Oct 2017 Author’s response to reviews: Reviewer #1: The manuscript was re-structured as suggested by the Reviewer. The sections of METHODS, RESULTS and DISCUSSION were re-arranged...

bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. they were synthesized by different methods. herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using sulfonic acid functionalized silica (sio2-pr-so3h) in aqueous media is reported. the advantages of this new metho...

1,3-dibromo-5,5-dimethylhydantoin (dbh), as a cheap and commercially available reagent, is efficiently able to catalyze the synthesis of polyhydroquinoline derivatives and 12-aryl-8,9,10,12-tetrahydro[a] xanthene-11-ones via one-pot multi-component reactions. this novel synthetic method has the advantages of low cost and availability of the catalyst, short reaction times, high to excellent yiel...

A facile and highly efficient protocol was applied successfully to synthesize 4H-pyrimido[2,1,b]benzimiazoles and 4H-pyrimido[2,1,b]benzothiazoles through one-pot three-component cyclocondensation reactions of 2-aminobenzimidazole or 2-aminobenzothiazole with dimedone and aromatic aldehydes in the presence of guanidinium chloride under solvent-free conditions. The reactions us...

While some sequential electrophilic aromatic substitution reactions, known as tandem/domino/cascade reactions, have been reported for the construction of aromatic single skeletons, one of the most interesting and challenging possibilities remains the one-pot build-up of a complex aromatic molecule from multiple starting components, i.e., ultimately multi-component electrophilic aromatic substit...

The discovery of novel chemical reactions or reaction sequences that are able to generate useful chemical products may be regarded as the heart of organic chemistry. We present here concepts and methods on how to find and explore new multi component reactions, especially with automated combinatorial methods. This "combinatorial reaction finding" provides also a powerful tool to the understandin...