Cell division requires coordinated regulation of chromosome segregation and cytokinesis. Although much is known about the function of the protease separase in promoting sister chromosome separation, the role of separase during cytokinesis is unclear. We show that separase localizes to the ingressing furrow and midbody during cytokinesis in the C. elegans embryo. Loss of separase function during...

Cytokinesis ensures the proper partitioning of the nuclear and cytoplasmic contents into independent daughter cells at the end of cell division. Although the metazoan mitotic spindle has been implicated in the placement and advancement of the cleavage furrow, the molecules responsible for these processes have remained elusive. Recent studies have provided insights into the role of different mic...

The ventral furrow and posterior midgut invaginations bring mesodermal and endodermal precursor cells into the interior of the Drosophila embryo during gastrulation. Both invaginations proceed through a similar sequence of rapid cell shape changes, which include apical flattening, constriction of the apical diameter, cell elongation and subsequent shortening. Based on the time course of apical ...

alcium just got a promotion. Findings by Caroppo et al. (page 111) reveal that in addition to its many roles inside the cell, Ca 2 ϩ has a distinct extracellular purpose: it acts via a Ca 2 ϩ receptor (CaR) to regulate the function of gastric epithelial cells. It has been known for some time that extracellular Ca 2 ϩ can be sensed by the CaR. The team noted that a Ca 2 ϩ gradient was generated ...

ARTICLE HISTORY Received 3 August 2016 Revised 24 October 2016 Accepted 24 October 2016 ABSTRACT BAR domain proteins can regulate ‘membrane reservoirs’ that provide surface area and buffer membrane tension. Syndapin is an F-BAR and SH3 domain containing protein involved in cytoskeletal remodelling and endocytosis. The Syndapin F-BAR domain is uniquely versatile compared to others in the family ...

The process of cytoplasmic cleavage has been studied in thin sections of rat erythroblasts and the cells of mouse leukemia and Walker 256 carcinoma of the rat. The development of the cleavage furrow begins in relation to the mid-body, which, earlier, appears on the equatorial plane in association with the continuous fibers of the spindle. The earliest evidence of a cleavage furrow is the presen...

Rab11 is a small GTPase that regulates several aspects of vesicular trafficking. Here, we show that Rab11 accumulates at the cleavage furrow of Drosophila spermatocytes and that it is essential for cytokinesis. Mutant spermatocytes form regular actomyosin rings, but these rings fail to constrict to completion, leading to cytokinesis failures. rab11 spermatocytes also exhibit an abnormal accumul...

The low phosphorus (P) availability is considered one of the most limiting factors for suitable crop production in Brazilian Cerrado areas. We aimed to define best P fertilizer management maximum soybean and maize grain yield minimum soil adsorption new agricultural Two experiments were carried out a Hapludox (pH 5.0) over six years. first experiment evaluated five (correction maintenance): cor...

Contour Crafting is an emerging technology that uses robotics to construct free form building structures by repeatedly laying down layers of material such as concrete. The Contour Crafting technology scales up automated additive fabrication from building small industrial parts to constructing buildings. Tool path planning and optimization for Contour Crafting benefit the technology by increasin...

this study was conducted in split plot design based on a randomized complete block design in naghadeh region, urmia, iran in 2009-10. two sowing patterns including a1) single row planting with 50 cm between-row spacing, and a2) two rows planting on the hill with 40 cm distance and 50 cm between-row spacing (40×50) were allocated to main plots and four furrow compactions including b1) control, b...