The main constituent of saffron, Crocus sativus L., is called Crocin (CR). Water-soluble carotenoids in CR possesses anti-inflammatory, analgesic, anti-edematous, as well anti-oxidant properties, to increase the number microtubules sheep brain and have neuroprotective effects. For example, Alzheimer's disease (AD), where harm hippocampal cortical neurons results memory cognitive impairment, amy...

Background and Aim: Diabetes can lead to reduced fertility in men by production of free radicals. Crocin (the effective component of saffron) with its antioxidant property can be effective in elimination of free radicals. We evaluated the effects of crocin on the reproductive parameters of the STZ –induced diabetic male Wistar rats. Materials and Method: Rats were made diabetic with...

  Objective(s): In this study, the effects of chronic administration of crocin, an active constituent of saffron, on blood pressures of normotensive and desoxycorticosterone acetate (DOCA) - salt induced hypertensive rats, were investigated.   Materials and Methods: Five week administration of three doses of crocin (50, 100 and 200 mg/kg/day) and spironolactone (50 mg/kg/day) in different...

Saffron is a spice derived from the flower of Crocus sativus L., which has special aroma, colour and odour influencing positively its economic value. In this context, ten saffron ecotypes were screened for their biochemical composition antioxidant activity. The samples also analysed using GC-MS LC-MS to determine content volatile phenolic compounds, respectively. results revealed statistically ...

Moroccan saffron is mainly produced in the South, on a limited zone of about 600 ha. In 2005, the National Institute of Agronomic Research, Morocco, carried out a study on trying saffron crop in some underprivileged regions under diverse environments, as way to propose alternative crop for the socio-economic development of rural area. The preliminary results obtained during this first year are ...

Introduction: In this study, two constituents of saffron stigma (crocin and safranal) were tested for possible cytotoxic and antitumoral activity using brine shrimp and potato disc assays. Methods: In the brine shrimp assay, three wells containing 10 nauplii were tested for each concentration. After 24h, the number of the nauplii was counted. To investigate the antimicrobial activity of safr...

Objective: Crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. The present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. Materials and Methods: Local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hi...

Introduction and Aim: Multiple sclerosis (MS) is a complex neurological condition might emerge as result ofcomplex combination of genetic risk factors with environmental triggers, including oxidative stress. in this study we aimed to evaluate the effects oral Crocin on stress patients MS. 
 Materials Methods: Adjunct standard treatment, group (20 patients) received 30-mg/day (15 mg twice d...