The effect of exposure to carcinogenic polycyclic aromatic hydrocarbons adsorbed onto respirable air particles (PM2.5, diameter < 2.5 μm) on DNA adducts and chromosomal aberrations was repeatedly studied in Prague, Czech Republic, in groups of policemen working in the downtown area and in bus drivers. Personal exposure was evaluated using personal samplers during working shifts. DNA adducts wer...

The in vivo cytogenetic effects of 2-trans hexenal were evaluated by investigating chromosomal aberrations and sperm head abnormalities in the bone marrow cells of laboratory bred Swiss albino mice. Single intraperitoneal injections of 8, 16 or 32 μl per kg bodyweight resulted in dose-dependent decreases in the mitotic index, significantly so at the higher doses and earlier times. Chromosomal a...

Cyclophosphamide is one of most commonly used in malignant lymphomas. The antioxidants such as Vit C inhibits the toxicity of mutagens/carcinogens in animals and Humans. The protective effects of ascorbic acid (AA) on cyclophosmide (CP) induced cytogenetic damage was evaluated suing analysis of chromosomal aberrations in human lymphocytes in vitro. When cultures were treated with various doses ...

BACKGROUND Cytogenetic studies of malignant peripheral nerve sheath tumours (MPNSTs) and malignant triton tumours (MTTs) are rare. AIMS To undertake cytogenetic analysis of these tumours. METHODS Conventional cytogenetic analysis of 21 MPNSTs and MTTs from 17 patients (nine with peripheral neurofibromatosis (NF1)) was carried out using standard culture and harvesting procedures. For a more ...

Autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous disorder characterized by focal cyst formation from any part of the nephron. The molecular bases include germinal mutation of either PKD1 or PKD2 genes, enhanced expression of several protooncogenes, alteration of the TGF-alpha/EGF/EGF receptor (EGFR) axis, and disturbed regulation of proliferative/apoptosis pat...

To date there are only few reports concerning chromosomal changes in desmoid tumors. To extend the knowledge in this field we examined 19 samples from the patients diagnosed with desmoid tumors. In the present study formalin-fixed and paraffin-embedded desmoid tumors were analyzed using fluorescence in situ hybridization (FISH) with a-satellite probes for chromosomes X, Y, 8 and 20. Chromosomal...

Aim. Fertility disorders are one of the most common problems reproductive medicine. Chromosomal abnormalities play a crucial role in failure. The main purpose our study was to determine types and frequency chromosomal aberrations couples with history infertility. Methods. Karyotyping performed 652 failure between 2004 2022, including 203 primary infertility (PI), 240 recurrent pregnancy loss (R...

Cytogenetic abnormalities at diagnosis are important prognostic indicators in acute myeloid leukemia (AML). AML is categorized into 3 risk groups according to cytogenetic abnormalities; favorable, intermediate, and unfavorable. A new cytogenetic risk group called the monosomal karyotype (MK) had been identified in AML in the unfavorable cytogenetic risk group. The MK was reported to be associat...