Yeosinsan, an herbal formula composed of roots Paeonia lactiflora and tubers Cyperus rotundus, was reported as a possible anti-inflammatory pro-fertility drug. However, the safety Yeosinsan has not yet been previously investigated. The acute chronic oral toxicity estimated using female male Sprague Dawley rats. During administration period, rats were monitored for mortality, body weight changes...

To explore the effect of monosialotetrahexosylganglioside sodium on cortical neurogenesis in traumatic brain injury rats. Thirty Sprague–Dawley rats were randomly divided into control group, saline group and group. The model was prepared with hydraulic controllable device received sham operation. levels oxidative stress, nerve damage, new born neurons, learning memory capabilities assessed seru...

Gastroenterology Medicine & Research Evaluation of Disease Index, Colon Damage Score, and Microbial Analysis Intestinal Flora after Treatment with the Novel Test Formulation in TNBS-Induced Colitis Sprague Dawley Rats Mahendra Kumar Trivedi1 Snehasis Jana2* 1Trivedi Global, Inc, Henderson, Nevada, USA 2Trivedi Science Laboratory Pvt. Ltd., Thane-West, Maharashtra, India *Corresponding author:Sn...

Non-alcoholic fatty liver disease (NAFLD) is an important cause of liver-related morbidity and mortality. The aim of this work was to establish and characterize a nutritional model of NAFLD in rats. Wistar or Sprague-Dawley male rats were fed ad libitum a standard diet (ST-1, 10 % kcal fat), a medium-fat gelled diet (MFGD, 35 % kcal fat) and a high-fat gelled diet (HFGD, 71 % kcal fat) for 3 or...

Objective(s): Broad range of metabolic changes associated with highly active antiretroviral therapy (HAART) has been reported over decades including reproductive perturbations. The current study aimed at investigating the role of Hypoxis hemerocallidea (Hyp) in the seminal and morphometric alterations in the testes of streptozotocin-nicotinamide-induced diabetic rats under HAART.Materials and M...

BACKGROUND The key biological determinants that promote restenosis in the setting of diabetes have not been elucidated. There is no accepted animal model to study restenosis in diabetes. METHODS AND RESULTS We evaluated 2 models of diabetes mellitus: (1) streptozotocin (STZ)-treated Sprague-Dawley rats (type I diabetes) versus regular Sprague-Dawley rats and (2) obese Zucker rats (type II dia...

BACKGROUND The search for a relatively cheap, widely available, widely accepted and effective contraceptive of plant origin; that is equally non-invasive in administration, non-hormonal in action, non-toxic and that is relatively long-acting, generated our interest in this study (in order to meet the increasing need for population control). The aim of this study was to determine the effects of ...

The pancreas plays an important role in the homeostasis of zinc (Zn), a nutritionally essential metal. In several previous studies, Zn ions induced inflammatory changes exocrine pancreas; however, little is known about complexes. this study, we microscopically, immunohistochemically, and ultrastructurally examined pancreatic lesions Sprague-Dawley (SD) rats by 4-week repeated oral dose toxicity...

Annona muricata L. (Annonaceae) is widely used in the Amazon and Carribean natural medicine as an antiparasitic, insecticidal, sedative astringent for diarrhea among others. In Nigeria however, under-utilized species of plants. This study investigated antidepressant ambulatory effect A. muricata, using open field test forced swim tests on Sprague-Dawley rats administered ethanol stem-bark extra...