Perinatal undernutrition is known to disturb reproductive development, in particular by delaying the onset of puberty in certain species. Using a rat model, we studied whether hypernutrition after birth can rescue the delayed onset of puberty in intrauterine undernourished female rats. Pregnant rats were divided into two groups: the maternal normal nutrition (mNN, n = 8) and maternal undernut...

Prochloraz (PCZ) is an imidazole fungicide that inhibits gonadal steroidogenesis and antagonizes the androgen receptor (AR). We hypothesized that pubertal exposure to PCZ would reduce testosterone production and delay male rat reproductive development. Sprague Dawley rats were dosed by gavage with 0, 31.3, 62.5, or 125 mg/kg/day of PCZ from postnatal day (PND) 23 to 42 or 51. There was a signif...

BACKGROUND The mechanism that initiates the onset of puberty is largely unknown but the age of onset is mainly under genetic control and influenced by environmental factors including nutrition. Familial forms of constitutional delay of puberty (CDP) suggest the involvement of genetic factors. The purpose of this study is to describe the presentation and the mode of inheritance of CDP in a serie...

introduction: pulmonary tuberculosis is major problem worldwide and it is estimated one third the world population are already infected and each year 9 million people develop full blown tuberculosis of these 3 million die of the disease, annually. delay in diagnosis and treatment are major problems that play a significant role in all aspect of the disease from patient treatment to transmission ...

the gnrh analogue has been shown to be effective in the treatment of precocious puberty when given as a daily subcutaneous injection. we studied the effectiveness of a long-acting gnrh analogue, triptoreline, for the treatment of central precocity, by suppressing gonadotropin and estradiol secretion in three children with true precocious puberty. one month after single dose intramuscular inject...

Urinary growth hormone (uGH) excretion and serum growth hormone concentrations have been compared in three groups of children. Group 1 consisted of 21 children who had had cranial irradiation as part of their treatment for acute lymphoblastic leukaemia; group 2, 18 normal children; and group 3, 12 boys with constitutional delay in growth and puberty who were in early puberty. Children in groups...

the present research is a field study in order to investigate the attitude of mothers towards education of puberty problems, in secondary school children, girls age between 11-1.4 years old, in tehran, 1993.   the instrument used was a questionnaire and data was collected through a two section questionnaire. the first part contained demographic information (10 items), and the second section pos...

A survey has been given of the development of voice in adolescents. The voice parameters fundamental frequency during reading of a standard text and phonetograms where compared with the pubertal development and the androgens and estrogens in boys and girls respectively. The review of adolescent voice development in girls and boys briefly present the core results of the study “Normal Development...

INTRODUCTION Turner Syndrome (TS) is caused by monosomy or structural abnormalities of the X chromosome, with a prevalence of about 1/2000 females live birth. Most important clinical features of TS are short stature and gonadal failure. Approximately one third of girls with TS may undergo spontaneous puberty. Here we report on the case of a girl with a rare 45X0/47XXX mosaic TS exhibiting a pre...