arthritis refers to different medical conditions associated with disorder of the primary structures that determine joint functions such as bones, cartilage and synovial membranes. drug discovery and delivery to retard the degeneration of joint tissues are challenging. current treatments of different arthritis involves administration of ideal non-steroidal anti-inflammatory drugs (nsaids) but ar...

background: factor viii inhibitor is one of the most problems in the treatment of hemophilia. patients with hemophilia who have inhibitors are capable of severe hemorrhage and treatments of these patients are more expensive and more difficult than those patients without inhibitor. the aim of present study was to determine the prevalence of inhibitor and to assess the necessity of screening of t...

the objective of this study is to study the effect of citrus medica in urolithiasis induced by ethylene glycol model. a number of 24 male wistar albino rats (250-300 g) were divided in to 4 groups namely group i (normal control), group ii (model control), group iii (standard-treated, cystone – 750 mg/kg) and group iv (citrus medica – 250 mg/kg). except group i, ethylene glycol (0.75% v/v in dri...

a new anti-corrosion compound, melamine formaldehyde (mf), was formulated by the addition of proper amount of formaldehyde to melamine under specific conditions. this compound was mixed with a novel nano powder, which was extracted from corn cob ash containing sio2 particles, in order to improve its corrosion inhibition efficiency. this inhibitor provides a high level of protection for steel su...

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conclusions special high-risk groups, including patients with ltbi, should be treated before receiving tnf-α inhibitors. the tuberculin skin test (tst) is a somewhat cost-effective test for the diagnosis of ltbi. however, its usefulness with respect to false results should be re-evaluated in this situation. results there were somewhat different approaches proposed by various researchers regardi...

Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...

Background: Short children face many problems throughout their lives. Consumption of growth hormone and the drugs such as Letrozole, Oxandrolone, and Anastrozole can increase the growth of children and adolescents. There is not an overall estimate of the effects of Letrozole, Oxandrolone, and Anastrozole on the growth of children and adolescents with Idiopathic Short Stature (ISS). There are di...