BACKGROUND Underuse and overuse of diagnostic tests have important implications for health outcomes and costs. Decision support technology purports to optimize the use of diagnostic tests in clinical practice. The objective of this review was to assess whether computerized clinical decision support systems (CCDSSs) are effective at improving ordering of tests for diagnosis, monitoring of diseas...

Experts’ reasoning in which selects the final diagnosis from many candidates consists of hierarchical differential diagnosis. In other words, candidates gives a sophisticated hiearchical taxonomy, usally described as a tree. In this paper, the characteristics of experts’ rules are closely examined from the viewpoint of hiearchical decision steps and and a new approach to rule mining with extrac...

Prostate cancer is diverse in clinical presentation, histopathological tumor growth patterns, and survival. Therefore, individual assessment of a tumor's aggressive potential is crucial for clinical decision-making in men with prostate cancer. To date a large number of prognostic markers for prostate cancer have been described, most of them based on radical prostatectomy specimens. However, in ...

Stress echocardiography is increasingly used in the management of patients with valvular heart disease and can aid in evaluation, risk stratification and clinical decision making in these patients. Evaluation of symptoms, exercise capacity and changes in blood pressure can be done during the exercise portion of the test, whereas echocardiographic portion can reveal changes in severity of diseas...

The paper describes several types of efficiency enhancements of 'classical' rule-based diagnostic expert systems. The blackboard control structure enables to explore more knowledge bases of the same syntax in parallel, the taxonomy structures make fast zooming of attention possible and provide additional inference mechanism based on inheritance principles. The applicability of the enhancing tec...

pasteurella multocida (p. multocida) is an important pathogen of various domestic animals. the outer membrane proteins (omps) play a major role in pathogenesis and immunogenicity of p. multocida. the aim of the study was to develop indirect enzyme linked immuno sorbant assay (elisa) based on omps to ascertain the antibody titers in animals post-infection or to gauge the potency of vaccine. the ...