Sao Paulo Med J/Rev Paul Med 2002; 120(5):131. A very positive phenomenon is taking hold within the Brazilian medical scene: the idea that it is possible to get advance warning of diseases by detecting markers (biochemical, hormonal, immunological and anatomical) that would make it possible to alter the natural history of a disease. Such actions, called check-ups, screening or early detection, ...

The ubiquitin proteasome system (UPS) comprises hundreds of different conjugation/deconjugation enzymes and multiple receptors that recognize ubiquitylated proteins. A formidable challenge to deciphering the biology of ubiquitin is to map the networks of substrates and ligands for components of the UPS. Several different receptors guide ubiquitylated substrates to the proteasome, and neither th...

Prior research indicated that information processing is influenced by the proximity of the hands to information: visuospatial processing is fostered near the hands, whereas textual processing might not be affected or even inhibited near the hands. This study investigated how the proximity of the hands to digital information in pop-ups influences learning outcomes on multi-touch devices. Dependi...

Regulated turnover of proteins in the cytosol and nucleus of eukaryotic cells is primarily performed by the ubiquitin-proteasome system (UPS). The UPS is involved in many essential cellular processes. Alterations in this proteolytic system are associated with a variety of human pathologies, such as neurodegenerative diseases, cancer, immunological disorders and inflammation. The precise role of...