In den letzten Jahren ist der Funktionsumfang von Softwareanwendungen immer stärker angestiegen. Solche hochfunktionellen Anwendungen (HFA) sind sehr komplex geworden, weil sie die Bedürfnisse großer und heterogener Gruppen von Benutzern mit unterschiedlichem Kenntnisstand, unterschiedlicher Erfahrung und auch für verschiedene Aufgabenbereiche zufrieden stellen müssen (Fischer 2001). Trotzdem s...

Stability studies play a critical role in assuring product quality at all points in the vaccine life cycle. These studies used to determine vaccine expiry date and vaccine efficacy. Accelerated stability and long term stability study performed for three batches of trivalent oral poliomyelitis vaccine (OPV) and three batches of monovalent OPV (type1) manufactured by Razi institute. After samplin...

We would like to thank the editors and referees for their considerable efforts that improved our paper, and all of the discussants for their feedback, and their thoughtful and stimulating comments. Linear models are central in applied statistics, and inference for adaptive linear modeling is an important active area of research. Our paper is clearly not the last word on the subject! Several of ...