نتایج جستجو برای: directed inhibition
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Background: Advanced papillary thyroid cancer (PTC) and anaplastic (ATC) are the leading causes of endocrine death. Mutations in MAP kinase (MAPK) pathway common PTC ATC. Recently, combination dabrafenib (BRAFi) trametinib (MEKi) was approved for treatment BRAF-mutant However, combined BRAF/ MEK inhibition is rarely curative ATC patients has had limited responses PTC. Here, we identify an induc...
Introduction: Self directed learning has become a focus for nursing education in the past few decades due to the complexity and changes in nursing profession development. The relationship between self directed learning and learning styles is detectable in different learning situations. This study was performed to determine nursing students' readiness for self-directed learning and also identify...
Serology improves influenza diagnosis by capturing cases missed by reverse transcriptase PCR (RT-PCR). We prospectively evaluated microneutralization and hemagglutination inhibition assays for 2009 influenza A (H1N1) virus diagnosis among 24 RT-PCR-confirmed cases and 98 household contacts. Compared to hemagglutination inhibition, microneutralization demonstrated a higher level of concordance w...
Antisense RNAII is a replication control element encoded by promiscuous plasmid pMV158. RNAII binds to its complementary sequence in the copG-repB mRNA, thus inhibiting translation of the replication initiator repB gene. In order to initiate the biochemical characterization of the pMV158 antisense RNA-mediated control system, conditions for in vitro transcription by T7RNA polymerase were set up...
Introduction: The need for self-learning and self-motivation in medical students is a necessity in today’s knowledge-based world. This study aimed to investigate the relationship between Self-directed learning and school motivation in medical students of Isfahan University of Medical Sciences. Methods: In this descriptive-correlational study 300 Medical students were selected through the simpl...
The marine brown alga Dictyota pfaffii from Atol das Rocas, in Northeast Brazil is a rich source of dolabellane diterpene, which has the potential to be used in future antiviral drugs by inhibiting reverse transcriptase (RT) of HIV-1. Reexamination of the minor diterpene constituents yielded three new dolabellane diterpenes, (1R*,2E,4R*,7S,10S*,11S*,12R*)10,18-diacetoxy-7-hydroxy-2,8(17)-dolabe...
The telomeric single-strand DNA binding protein protection of telomeres 1 (POT1) protects telomeres from rapid degradation in Schizosaccharomyces pombe and has been implicated in positive and negative telomere length regulation in humans. Human POT1 appears to interact with telomeres both through direct binding to the 3' overhanging G-strand DNA and through interaction with the TRF1 duplex telo...
Raltegravir (Isentress) is the first approved HIV integrase inhibitor. Agents in this class target a different viral enzyme compared with agents inhibiting reverse transcriptase and protease. A wide number of patients are currently susceptible to integrase inhibitors, including heavily antiretroviral-experienced patients harbouring drug-resistant viruses. The good tolerability and convenience o...
An enzyme system that replicates plasmids bearing the origin of the Escherichia coli chromosomes (oriC) has the following physiologically relevant features. The system (i) depends completely on low levels of exogenously furnished supercoiled oriC plasmids, (ii) uses only those plasmids that contain the intact oriC region of about 245 base pairs, (iii) initiates replication within or near the or...
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