BACKGROUND AND OBJECTIVES Alzheimer's disease (AD) shares certain etiological features with autoimmunity. Prevalence of autoimmunity varies between populations in accordance with variation in environmental microbial diversity. Exposure to microorganisms may improve individuals' immunoregulation in ways that protect against autoimmunity, and we suggest that this may also be the case for AD. Here...

INTRODUCTION Despite the evidence for preventing childhood morbidity and mortality, financial resources are cited as a constraint for Governments to scale up the key health interventions in some countries. We evaluate the cost effectiveness of implementing IMNCI program in India from a health system and societal perspective. METHODS We parameterized a decision analytic model to assess increme...

BACKGROUND Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in Argentina representing 34.2% of deaths and 12.6% of potential years of life lost (PYLL). The aim of the study was to estimate the burden of acute coronary heart disease (CHD) and stroke and the cost-effectiveness of preventative population-based and clinical interventions. METHODS An epidemiological mod...

AIMS Estimate the prevalence of cannabis dependence and its contribution to the global burden of disease. METHODS Systematic reviews of epidemiological data on cannabis dependence (1990-2008) were conducted in line with PRISMA and meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines. Culling and data extraction followed protocols, with cross-checking and consistency check...

OBJECTIVE Iran as a developing country is in the transition phase, which might have a big impact on the Burden of Disease and Injury (BOD). This study aims to estimate Burden of Disease and Injury (BOD) in Iran up to 2025 due to four broad cause groups using Disability-Adjusted Life Year (DALY). METHODS The impacts of demographic and epidemiological changes on BOD (DemBOD and EpiBOD) were ass...

Although one of the most harmful factors to health is noise, it often ignored in life cycle assessment (LCA) studies. Most researches regarding noise inclusion LCA focus on problem transport and very few works consider impact emitted by other sources. This study addresses effects generated cogeneration plants. The main objective assess environmental performance reduction system considering due ...