Six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride (50 mg/kg) to evaluate the pharmacokinetic parameters of the drug. Blood samples were collected before and at various time intervals after the administration of the drug. Serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. Non...

Evaluation and improvement of drug management process is essential for patient safety. The present study was performed whit the aim of assessing risk of drug management process in Women Surgery Department of QEH using HFMEA method in 2013. A mixed method was used to analys failure modes and their effects with HFMEA. To classify failure modes; nursing errors in clinical management model, for cla...

Evaluation and improvement of drug management process is essential for patient safety. The present study was performed whit the aim of assessing risk of drug management process in Women Surgery Department of QEH using HFMEA method in 2013. A mixed method was used to analys failure modes and their effects with HFMEA. To classify failure modes; nursing errors in clinical management model, for cla...

The human multidrug and toxin extrusion (MATE) transporter 1 contributes to the tissue distribution and excretion of many drugs. Inhibition of MATE1 may result in potential drug-drug interactions (DDIs) and alterations in drug exposure and accumulation in various tissues. The primary goals of this project were to identify MATE1 inhibitors with clinical importance or in vitro utility and to eluc...