Alzheimer's disease (AD), the most common form of dementia, is a neurodegenerative disease characterized by progressive cognitive deterioration together with declining activities of daily living and neuropsychiatric symptoms or behavioural changes. The oldest, on which most currently available drug therapies are based, is known as the "cholinergic hypothesis" and suggests that AD begins as a de...

Alzheimer is an age-dependent disease mostly with genetic origin. In this disorder, acetylcholine is decreased which results in deterioration of short-term memory. Many researches have been focused on finding new sources of medications with more potency and less side effects and investigating acetylcholinesterase inhibitors (AChEIs) has been the center of many researches. In the present study, ...

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results in this setting, detection rate of the disease is 34.86%, if the high normal titer for the wrights test titer assumed 1/80 and is 44.95% if the titer assumed 1/40, while elisa test had detection rate of 58.72% for those suspicious cases. furthermore, the detection rate for diagnosis of active brucellosis with 2me tests was 17.54% with high normal titer of 1/80 and was 59.64% with a high...

objective: generation 5 poly (amidoamine) dendrimers are promising multipotent gene delivery vectors that provide favorable dna condensation properties; however, their high toxicity limits their applications. toxicity of pamam dendrimers depends on their type, generation and applied dosage in a way that lower generations (lower than g5 dendrimers) and anionic dendrimers have lower toxicity than...

objective: various approaches have been offered for resolution of pain resulting from spinal cord injuries. one approach is the use of herbal and natural products. in the present research, as a preliminary study, we investigate the effect of crocin on chronic pain induced by contusion in the rat spinal cord (sci). methods: we randomly divided female wistar rats into five groups. groups i and ii...