Purpose Acupuncture has gained popularity since the National Institutes of Health 1997 Consensus Statement concluded that acupuncture is an effective anti-emetic for adult postoperative and chemotherapy-induced nausea and vomiting. The most commonly used acupuncture point to control nausea and vomiting is the Pericardium 6 (P6), or Neiguan point. Some evidence suggests that the anti-emetic effe...

Sapindus mukorossi is an extremely valuable medicinal plant, distributed in tropical and sub-tropical regions of Asia. The aim of present review is to form a short compilation of the phytochemical composition and pharmacological properties of this multipurpose tree. The main phytoconstituents isolated and identified from different parts of this plant are triterpenoidal saponins of oleanane, dam...

Studies on cardiovascular safety in cancer patients treated with highly or moderately emetogenic chemotherapy (HEC or MEC), who may have taken the antiemetic, aprepitant, have been limited to clinical trials and postmarketing spontaneous reports. Our study explored background rates of cardiovascular disease (CVD) events among HEC- or MEC-treated cancer patients in a population-based setting to ...

This guideline provides clinicians caring for children with an approach to assessing the acute emetogenic potential of antineoplastic therapies. It was developed by an international, inter-professional panel of clinicians and researchers using AGREE and CAN-ADAPTE methods. The emetogenicity of antineoplastic agents was evaluated and ranked as high, moderate, low, or minimal. The emetogenicity o...

The anti-emetic effects of domperidone were evaluated under double-blind conditions in twenty-four patients with acute vomiting randomly assigned to treatment either with 10 mg i.m. domperidone (six female, five males) or with placebo (seven females, six males). The therapeutic results were better with domperidone and the differences from placebo were statistically significant (p less than 0.02...

BACKGROUND The aim of the present study was to compare anti-emetic efficacy of low dose midazolam premedication (35 microg/kg) 15 minutes before induction of anesthesia with midazolam (35 microg/kg) administered intravenously 30 min before conclusion of surgery, in patients undergoing lower abdominal surgery under general anesthesia. METHODS Sixty patients were assigned to one of three equal ...

Postoperative nausea and vomiting continue to be problematic areas in anesthesia as evidenced by frequent reports of therapies in the literature. No single therapy has been proven curative for all cases, in part because of the several emetic centers, all of which may be blocked by different classes of drugs and the diverse risk factors which act alone or in combination to cause vomiting. Identi...

Data from two published and one new meta-analysis were reviewed to compare the antiemetic efficacy of three different anaesthetic regimens: (i) propofol anaesthesia compared with another anaesthetic (control); (ii) anaesthesia without nitrous oxide compared with the same anaesthetic with nitrous oxide (control); (iii) propofol anaesthesia without nitrous oxide (TIVA) compared with another anaes...

of trypanosomiasis by intravenous injection of tartar emetic or other soluble salts of antimony, it has been found that though they quickly free the peripheral blood from trypanosomes, still the parasites remain in the internal organs. So far, therefore, the treatment of trypanosomiasis by means of intravenous injection of soluble salts of antimony has not been a permanent success. In kala-azar...

A prospective trial was performed to better assess the risk of nausea and vomiting and the rescue value of tropisetron (TRO), a 5-HT3 receptor antagonist, in 88 patients undergoing fractionated radiotherapy to the abdomen or to large supradiaphragmatic fields and failing a first anti-emetic trial with metoclopramide (MET). Nausea was graded 0 (absent), 1 (mild), 2 (moderate) and 3 (severe). Nau...