Objective: Cutaneous wound healing involves multiple cooperative molecular processes such as inflammation, angiogenesis, wound contraction, granulation tissue formation, reepithelialization, and matrix deposition. We studied the effects of topical estrogen on wound healing in male rats. Methodology: This experimental study was done on 40 male rats. A circular wound with a diameter of 2cm was in...

PURPOSE The aim of this study was to compare the effect on corneal wound healing of 3 differently manufactured blood derivatives [autologous serum (AS), platelet-rich plasma, and serum derived from plasma rich in growth factors (s-PRGF)]. METHODS Scratch wound-healing assays were performed on rabbit primary corneal epithelial cultures and human corneal epithelial cells. Additionally, mechanic...

BACKGROUND Activin B has been reported to promote the proliferation and migration of keratinocytes in vitro via the RhoA-JNK signaling pathway, whereas its in vivo role and mechanism in wound healing process has not yet been elucidated. PRINCIPAL FINDINGS In this study, we explored the potential mechanism by which activin B induces epithelial wound healing in mice. Recombinant lentiviral plas...

Human recombinant epidermal growth factor (hEGF) was evaluated in various corneal wound healing models in the rabbit. Human EGF accelerated epithelial wound healing in corneal reepithelialization, anterior-keratectomy, and alkali-burn models at concentrations of 10-500 micrograms/ml given four times daily (qid). In the corneal reepithelialization model, 100 micrograms/ml of hEGF qid produced a ...

Intestinal epithelial cell migration plays a key role in gastrointestinal mucosal barrier formation, enterocyte development, differentiation, turnover, wound healing, and adenocarcinoma metastasis. Chemokines, through engagement of their corresponding receptors, are potent mediators of directed cell migration and are critical in the establishment and regulation of innate and adaptive immune res...

Aims—To investigate if the amniotic membrane (AM) promotes epithelial migration while inhibiting stromal remodelling associated with corneal haze after excimer laser keratectomy. Methods—A wound 150 μm in depth and 6.0 mm in diameter was produced in 40 rabbits using an excimer laser. One eye was randomly chosen to be covered by the AM while the other eye served as a control. Epithelial wound he...

Delayed or impaired wound healing in aging skin poses major medical, social, and economic challenges, yet a systematic understanding of the contributing cellular molecular alterations is lacking. In this work, we use single-cell RNA sequencing to interrogate differences across epithelial, fibroblast, immune cell types wounds young aged animals. We have identified changes their subset compositio...

Abstract Corneal epithelium responds to insults with a rapid wound healing, which is essential for maintaining vision. The proper balance of apoptotic and proliferation-stimulating pathways critical normal regeneration. Pituitary adenylate cyclase activating polypeptide (PACAP) an important growth factor during the development nervous system exerts cytoprotective effects in injuries. aim presen...

Honey is recognized traditionally for its medicinal properties and also appreciated as a topical healing agent for infected and noninfected wounds. This study evaluates impact of honey-based occlusive dressing on nonhealing (nonresponding to conventional antibiotics) traumatic lower limb wounds (n = 34) through clinicopathological and immunohistochemical (e.g., expression of p63, E-cadherin, an...

The histological distribution of receptors for Ricinus communis Fraction 1 (RCA1) in oral carcinomas and in oral epithelial cells during wound healing has been studied by use of fluorescein-tagged RCA1. Biopsies from 15 human oral carcinomas and adjacent normal mucosa showed RCA1 receptors at the cell membranes in the basal and spinous layer of the normal epithelium, whereas receptors could not...