Villin is an actin-binding cytoskeletal protein required for brush-border formation in the normal small intestinal and renal proximal tubule epithelium. Villin is a marker of cell differentiation in small intestinal and renal cell lineages, and recent studies have shown villin to be highly expressed in 100% of intestinal-type Barrett's metaplasias. This epithelium is the single greatest risk fa...

Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide, and majority these cancers, arises from squamous cells. Despite multiple therapeutic strategies, five year survival rate esophageal cell carcinoma (ESCC) ranges between 15%-20%. Epithelial-mesenchymal transition (EMT) one key events in ESCC, which associated with recurrence, metastasis low rate. Cancer stem cells (...

Preinvasive lesions of squamous cell carcinoma are well defined morphologically and provide a model for multistage carcinogenesis. Since alterations in the p53 tumor suppressor gene occur frequently in invasive esophageal squamous cell carcinoma, we examined a set of preinvasive lesions to investigate the timing of p53 mutation. Surgically resected tissues from nine patients with esophageal squ...

Esophageal cancer is one of the most aggressive malignancies gastrointestinal tract, characterized by high malignancy potential and poor prognosis. Surgical treatment standard for localized esophageal cancer, but results only surgery locally advanced tumors remain unsatisfactory. The use neoadjuvant chemotherapy, as well chemoradiation therapy, leads to a downstaging tumor, improves its resecta...

The p21WAF1 protein is an important regulator of the cell cycle. Its expression and prognostic significance were investigated immunohistochemically in samples of normal esophageal squamous epithelium (n = 10), severe squamous cell dysplasia (n = 20), carcinoma in situ (n = 14), permanent esophageal squamous cell carcinoma cell lines (n = 3), and invasive squamous cell carcinomas treated either ...

There are unfortunately a relatively large number of cases of esophageal cancer in Iran as well as other countries, and one of the most difficult problems facing surgeons is the reconstruction of the esophagus and restoration of its function after excision of the tumor. From 1978 to 1987,20 patients (16 male, 4 female) ranging in age from 22 to 68 years were surgically treated for squamous...

Multiple primary malignancies are not rare. While metachronous triple cancers are rare and a triple tumor case involving maxillary sinus and tympanic membrane is exceptionally rare. We present such an extremely rare case with the index tumor of adenoid cystic carcinoma of the maxillary sinus and 14 years later esophageal cancer was observed as a metachronous tumor. One year after esophageal can...