Calcineurin inhibitors (CNIs) are typically used to prevent organ rejection and their use has significantly improved allograft survival rates with a marked reduction in rates. However, CNIs have been associated various side effects including nephrotoxicity, hypertension, gingival hyperplasia, hypertrichosis, hepatotoxicity, hyperkalemia, neurotoxicity. Significant intra-patient interpatient pha...

Reconstructive transplantation has emerged as clinical reality over the past decade. Long-term graft acceptance has been feasible in extremity and facial vascularized composite allotransplantation (VCA) under standard immunosuppression. Minimizing overall burden of lifelong immunosuppression is key to wider application of these non-life saving grafts. Allograft tolerance is the holy grail of ma...

A 19-year-old woman with type I neurofibromatosis requested reconstruction of her severe facial disfigurement caused by the plexiform neurofibroma of the right upper eyelid. Previously, she had glaucoma surgery for buphthalmus and enucleation with dermis fat transplantation. She was unable to wear prosthesis in the last year. Transverse palpebral resection of the lesion, lateral canthal reconst...

Cyclosporine-induced sebaceous hyperplasia (SH) is a well-documented entity, occurring in up to 30% of renal transplant patients treated with cyclosporine and has also been reported to occur following heart or hematopoetic stem cell transplantation (HCST). Cyclosporine has a stimulatory effect on undifferentiated sebocytes, resulting in the clinical and histologic findings in these patients. Se...

In mammals, facial branchiomotor (FBM) neurones are born in ventral rhombomere (r) 4 and migrate through r5 to dorsal r6 where they form the facial motor nucleus. This pattern of migration gives rise to the distinctive appearance of the internal genu of the facial nerve, which is lacking in birds. To distinguish between extrinsic cues and intrinsic factors in the caudal migration of FBM neurone...

Many researchers adopt Local Binary Pattern for pattern analysis. However, the long histogram created by Local Binary Pattern is not suitable for large-scale facial database. This paper presents a simple facial pattern descriptor for facial expression recognition. Local pattern is computed based on local gradient flow from one side to another side through the center pixel in a 3x3 pixels region...

Nonnegative Matrix Factorization (NMF) algorithms have been utilized in a wide range of real applications. NMF is done by several researchers to its part based representation property especially in the facial expression recognition problem. It decomposes a face image into its essential parts (e.g. nose, lips, etc.) but in all previous attempts, it is neglected that all features achieved by NMF ...

introduction: intraparotid neurofibromas of the facial nerve are extremely rare and mostly associated with neurofibromatosis type 1 (nf1). case report: this is a case of a healthy 40-year-old man, which underwent surgery for a preoperatively diagnosed benign parotid gland lesion. after identification of the facial nerve main trunk, a single large mass (6 x 3 cm) incorporating the upper nerve di...