We have characterized paired-pulse facilitation at Aplysia sensory neuron-to-motoneuron synapses. This simple form of very short-term synaptic plasticity displayed an unusual feature: it decreased dramatically with repeated testing. Synaptic depression at these synapses and this use-dependent decrease in paired-pulse facilitation occurred independently of each other. Paired-pulse facilitation w...

1. INTRODUCTION Group Support Systems (GSS) technology, which has been developed over the course of the last dozen years, has been initially researched in laboratory-based experiments. More recently, fieldwork has examined how GSS function in real world environments involving businessmen, diplomats, soldiers and students. GSS were originally designed to support discussion and decision making in...

Facilitation of quanta1 release has been thought to be maximal immediately after the first action potential in the presynaptic terminal. However, at the frog neuromuscular junction at 0°C no facilitation was observed in response to direct nerve depolarization when the interval between stimulus pairs was less than 10 msec (Dudel, 1988), while at intervals of 20 msec and beyond, facilitation was ...

1. We studied two-pulse facilitation and delayed release at 0 degree C, because at low temperature facilitation is enhanced and extended whereas delayed release is increased. Our major goal was to test, by a number of approaches, the residual Ca2+ hypothesis of facilitation and delayed release. 2. As we increased the interval between pulses from 30 to 100-200 ms facilitation declined steeply. A...

an earlier overview of systematic reviews and a subsequent editorial on single-component versus multifaceted interventions to promote knowledge translation (kt) highlight complex issues in implementation science. in this supplemented commentary, further aspects are in focus; we propose examples from (kt) studies probing the issue of single interventions. a main point is that defining what is a ...

The action of cumulative doses of meprobamate on antidromic conditioning has been studied in spinal cats. Recurrent facilitation is greatly reduced or completely abolished by total doses ranging from 210 to 400 mg./kg. The depth of recurrent inhibition is not affected in a consistent manner by meprobamate, but the duration of inhibition is markedly increased in all experiments. This differentia...

Presynaptic potentials were studied during facilitation of transmitter release in the squid giant synapse. Changes in action potentials were found to cause some, but not all, of the facilitation during twin-pulse stimulation. During trains of action potentials, there were no progressive changes in presynaptic action potentials which could account for the growth of facilitation. Facilitation cou...

BACKGROUND Facilitation is emerging as an important strategy in the uptake of evidence. However, it is not entirely clear from a practical perspective how facilitation occurs to help move research evidence into nursing practice. The Canadian Partnership Against Cancer, also known as the 'Partnership,' is a Pan-Canadian initiative supporting knowledge translation activity for improved care throu...

The study describes and evaluates inter-organizational communication and relationships involving rural development management of community lands within specific perimetros florestais in Portugal. The research design is an exploratory research study approach that collected information with a mail questionnaire, interviews and information gleaned from community land association meetings and an in...