The effect of hyperglycemia per se on glucose uptake by muscle tissue was quantitated in six controls and six type II diabetics by the forearm technique, under conditions of insulin deficiency induced by somatostatin (SRIF) infusion (0.7 mg/h). Blood glucose concentration was clamped at its basal value during the first 60 min of SRIF infusion and then raised to approximately 200 mg/dl by a vari...

A case of intramuscular hemangioma of the right forearm and hand muscle is presented in this study. This tumor may infiltrate the muscle and be misdiagnosed as a malignant neoplasm. The patient, a 14-year-old girl, presented to the clinic with right forearm and hand pain and swelling which began when she was 2 years old and had been gradually increasing in size. Because the mass might have been...

This study examines and compares the response of two upper extremity test devices under driver-side air bag deployment to contribute to the development of dummy surrogates for the investigation of primary contact forearm injuries during air bag deployments. The first of these test devices, the SAE 5’ Percentile Female Arm (SAE Arm), is an anthropomorphic representation of a small female forearm...

BACKGROUND Occupational computer use has been associated with upper extremity musculoskeletal disorders (UEMSDs), but the etiology and pathophysiology of some of these disorders are poorly understood. Various theories attribute the symptoms to biomechanical and/or psychosocial stressors. The results of several clinical studies suggest that elevated antagonist muscle tension may be a biomechanic...

In 9 patients with essential hypertension, we tested whether a high-dose (12 mg. min(-1)) vitamin C infusion into the brachial artery, by improving endothelium-dependent vasodilatation, would also attenuate the insulin resistance of deep forearm tissues. We measured the effect of vitamin C on acetylcholine (Ach)-induced vasodilatation and on forearm glucose uptake during systemic hyperinsulinem...

The mechanisms by which high salt intake increases vascular resistance in hypertensive humans are not clear. This study examined the possibility that salt loading produces structural changes of the forearm resistance vessels in hypertensive patients. Seventeen patients with essential hypertension were given 7 days of 70 mEq and 345 mEq sodium diet. Patients were arbitrarily divided into two gro...

BACKGROUND Endothelium-dependent vasodilation is abnormal in experimental models of diabetes mellitus. We postulated that abnormalities of endothelial function are also present in patients with insulin-dependent diabetes mellitus and may contribute to the pathogenesis of vascular disease in these individuals. METHODS AND RESULTS Vascular reactivity was measured in the forearm resistance vesse...

BACKGROUND Conflicting evidence exists concerning whether insulin-induced vasodilation plays a mechanistic role in the regulation of limb glucose uptake. It can be predicted that if insulin augments blood flow by causing tissue recruitment, this mechanism would enhance limb glucose uptake. METHODS AND RESULTS Twenty healthy subjects were studied with the forearm perfusion technique in combina...

Tschakovsky, M. E., and R. L. Hughson. Ischemic muscle chemoreflex response elevates blood flow in nonischemic exercising human forearm muscle. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H635–H642, 1999.—We tested the hypothesis that forearm blood flow (FBF) might be reduced during forearm exercise when a vasoconstrictor response was evoked by calf exercise during calf ischemia (CE 1 I). In...