نتایج جستجو برای: gene ontology
تعداد نتایج: 1180795 فیلتر نتایج به سال:
Candidate gene identification deals with associating genes to underlying biological phenomena, such as diseases and specific disorders. It has been shown that classes of diseases with similar phenotypes are caused by functionally related genes. Currently, a fair amount of knowledge about the functional characterization can be found across several public databases; however, functional descriptor...
The goal of this conference is to bring together scientists who are developing standards and ontologies for describing microarray and other high throughput functional genomics experiments. The topics will include: • The Gene Ontology (GO) project • Anatomy and phenotype ontologies • Disease ontologies • Chemical compounds and treatments • Inter-ontology mapping • Tools for ontology development ...
Introduction: Autism is a nervous system disorder, and since there is no direct diagnosis for it, data mining can help diagnose the disease. Ontology as a backbone of the semantic web, a knowledge database with shareability and reusability, can be a confirmation of the correctness of disease diagnosis systems. This study aimed to provide a system for diagnosing autistic children with a combinat...
The Gene Ontology Next Generation Project (GONG) is developing a staged methodology to evolve the current representation of the Gene Ontology into DAML+OIL in order to take advantage of the richer formal expressiveness and the reasoning capabilities of the underlying description logic. Each stage provides a step level increase in formal explicit semantic content with a view to supporting valida...
The Gene Ontology (GO) (http://www.geneontology.org) is a community bioinformatics resource that represents gene product function through the use of structured, controlled vocabularies. The number of GO annotations of gene products has increased due to curation efforts among GO Consortium (GOC) groups, including focused literature-based annotation and ortholog-based functional inference. The GO...
Purpose: To explore the molecular targets of Guanxin Danshen Dripping Pills (GXDS) in regulating psycho-cardiology disease through identifying its components by UPLC-MS/MS and network pharmacology approach.
 Methods: Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was adopted to determine GXDS’ main constituents. SwissTargetPrediction similarity ensemble appro...
BACKGROUND A systems biology approach to cardiac physiology requires a comprehensive representation of how coordinated processes operate in the heart, as well as the ability to interpret relevant transcriptomic and proteomic experiments. The Gene Ontology (GO) Consortium provides structured, controlled vocabularies of biological terms that can be used to summarize and analyze functional knowled...
The COVID-19 coronavirus, which primarily affects the lungs, is source of disease known as SARS-CoV-2. According to “Smoking and COVID-19: a scoping review,” about 32% smokers had severe case pneumonia at their admission time 15% non-smokers this pneumonia. We were able determine genes expressed differently in each group by comparing expression gene transcriptomic datasets patients, smokers, he...
امروزه استفاده از اطلاعات ژنتیکی افراد در تشخیص و رده بندی انواع بیماری ها از جمله سرطان ها، مورد توجه قرار گرفته است. یکی از بهترین و دقیق ترین روش ها در این زمینه، بررسی مقادیر بیان ژنی در افراد مختلف توسط فناوری ریزآرایه می باشد. یکی از مشکلات داده های ریزآرایه کم بودن تعداد نمونه ها در مقایسه با تعداد ژن ها است. این مسیله سبب کاهش دقت رده بندی و افزایش هزینه های محاسباتی و آزمایشگاهی می شود...
Motivation: Bio-ontologies, such as the Gene Ontology, represent important sources of prior knowledge that may be automatically integrated to support predictive data analysis tasks. The assessment of similarity of gene products provides the basis for the implementation of classification tools and the automated validation of functional associations. This study discusses alternative techniques fo...
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