In this thesis, we have proposed ACTOM, a Topic Map building approach based on an automated processtaking into account multilingual documents and Topic Map evolution according to content and usage changes.To enrich the Topic Map, we are based on a domain thesaurus and we propose to explore all potentialquestions related to source documents on order to represent usage in the Topic Ma...

Technological advances have made possible the development of high-resolution genetic linkage maps for the mouse. These maps in turn offer exciting prospects for understanding mammalian genome evolution through comparative mapping, for developing mouse models of human disease, and for identifying the function of all genes in the organism.

Modern high-throughput DNA sequencing has made it possible to inexpensively produce genome sequences, but in practice many of these draft genomes are fragmented and incomplete. Genetic linkage maps based on recombination rates between physical markers have been used in biology for over 100 years and a linkage map, when paired with a de novo sequencing project, can resolve mis-assemblies and anc...

Molecular genetic maps are commonly constructed by analyzing the segregation of restriction fragment length polymorphisms (RFLPs) among the progeny of a sexual cross. Here we describe a new DNA polymorphism assay based on the amplification of random DNA segments with single primers of arbitrary nucleotide sequence. These polymorphisms, simply detected as DNA segments which amplify from one pare...

Many documents and more generally many resources are produced or used in an e-learning application. In order to capitalize these resources and to facilitate their access, we propose to organise them in a “learning organisational memory” (MEMORAe project). In this paper, we present the context of use, the needs and the contents of this memory. We describe the ontologies and the Topic Maps formal...

Nowadays, data handled by an institution or company is spread out by more than one database and lots of documents of different types. To extract the information implicit in that data, it is necessary to pick parts from those various archives. To obtain a general overview, those information slices should be gather. Different approaches can be followed to achieve that integration, ranging from th...

Traditionally, genetic risk maps consider genotypic differences in a small number of single markers. However, a more recent approach considers a very large set of input variables some of them with very little effect and haplotypes with several consecutive markers instead of genotypes. While a bidimensional map can only show the first of the two approaches, a 3D map together with a powerful visu...

Based on a two-way pseudo-testcross strategy, high density and complete coverage linkage maps were constructed for the maternal and paternal parents of an intraspecific F2 pedigree of Populus deltoides. A total of 1,107 testcross markers were obtained, and the mapping population consisted of 376 progeny. Among these markers, 597 were from the mother, and were assigned into 19 linkage groups, sp...

Development of tools to jointly visualize the genome and the epigenome remains a challenge. chroGPS is a computational approach that addresses this question. chroGPS uses multidimensional scaling techniques to represent similarity between epigenetic factors, or between genetic elements on the basis of their epigenetic state, in 2D/3D reference maps. We emphasize biological interpretability, sta...