نتایج جستجو برای: genotype distribution
تعداد نتایج: 692531 فیلتر نتایج به سال:
background: coronary artery disease (cad) is one of the leading causes of death and disability around the world. interaction between genetic and environmental factors determines susceptibility of an individual to develop coronary artery disease . lipoprotein lipase (lpl) play an important role in the metabolism of hdl-c ( high density lipoprotein cholesterol ), ldl-c (low density lipoprotein ch...
The distribution of polymorphisms related to glutathione S-transferases (GST) has been described in different populations, mainly for white individuals. We evaluated the distribution of GST mu (GSTM1) and theta (GSTT1) genotypes in 594 individuals, by multiplex PCR-based methods, using amplification of the exon 7 of CYP1A1 gene as an internal control. In São Paulo, 233 whites, 87 mulattos, and ...
Parvovirus B19 comprises three distinct genotypes (1, 2, and 3). The distribution of B19 genotypes has not before been examined in South Africa. Two hundred thirty-nine laboratory samples submitted to a diagnostic virology laboratory for parvovirus DNA detection were analyzed retrospectively. Of the 53 PCR-positive samples investigated, 40 (75.4%) were identified as genotype 1 by genotype-speci...
BACKGROUND Approximately 170 million people are infected with Hepatitis C virus (HCV) worldwide, making it one of the world's major infectious diseases. There are no published population based studies about the prevalence of HCV genotypes in Bahrain. OBJECTIVES Therefore, the aim of the present study was to investigate the prevalence and distribution of HCV genotypes and subtypes among a larg...
Background and purpose: Helicobacter pylorus is a well-recognized cause of chronic active gastritis, peptic ulcer disease (PUD) and linked to the development of gastric adenocarcinoma. Heat shock protein (HSP) acts as molecular chaperons in the folding of newly synthesized proteins in cells and assist in the refolding of damaged proteins.The HSP70-2 gene has a pst1 site due to an A to G transit...
The aim of the present study was to determine the association between sirtuin 1 (SIRT1), fibroblast growth factor receptor 2 (FGFR2) and signal transducer and activator of transcription 3 (STAT3) polymorphisms, and pituitary adenoma (PA) development, invasiveness, hormonal activity and recurrence. The present study included 143 patients with a diagnosis of PA. The reference group involved 808 h...
introduction: caveolin-1 (cav-1) is a scaffolding protein found in special structures of plasma membrane, known as caveolae. cav-1 can regulate many intracellular processes, including signal transmission and cholesterol metabolism. this protein plays an important role in the growth and differentiation of breast tissue and acts as a tumor suppressor gene as well. the aim of this study was to det...
BACKGROUND AND AIMS Little is known of hepatitis C virus (HCV) genotypes in HCV infected children. This retrospective, multicentre study investigated genotype distribution and correlation with clinical features and outcome in a large series of Italian children. METHODS Between 1990 and 2002, 373 HCV RNA positive children, consecutively recruited in 15 centres, were assayed for genotypes by a ...
BACKGROUND Genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been reported to be strongly associated with type 2 diabetes mellitus (T2DM) in Icelandic, Danish and American populations and further replicated in other European populations, African Americans, Mexican Americans, and Asian populations. The aim of the present study was to investigate the association of TCF...
background: migraine is a chronic neurological disorder, characterized by recurrent moderate to severe headaches. worldwide migraine a=ects nearly 15%. studies suggest that genes involved in the production of nitric oxide (no) may act as genetic factors for migraine. no synthase 3 (nos3) by expressing enzyme nos regulates endothelial derived no. one class of medications used as f...
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