Objective The aim is to compare complications and long-term outcome of two treatment modalities chronic anal fissure: chemical sphincterotomy by glyceryl trinitrate (GTN) cream lateral internal sphincterotomy. Background Treatment fissure achieved the reduction in tone sphincter either chemically or surgically. Patients methods In period from November 2013 October 2015, all patients who were ad...

OBJECTIVES To determine whether an increase in cardiac sympathetic activity produced by exercise or sublingual glyceryl trinitrate causes an increased rate of loss of fluorine-18 from the myocardium after intravenous [18F]6-fluorodopamine ([18F]F-DA) in normal volunteers. In addition, to determine the contribution of non-specific uptake of [18F]F-DA in the myocardium in patients with recent hea...

INHALATION of amyl nitrite causes abrupt vasodilatation and increase in cardiac output and intensifies the murmur of aortic stenosis.1 The transaortic systolic pressure gradient increases because of the increased ejection rate through the stenotic orifice. In muscular subaortic stenosis this effect is particularly marked,2-6 not only because of the increased ejection rate but also because the d...

The authors investigated the effect of repeated inunction with 2 per cent glyceryl trinitrate in lanolin on the blood flow and skin temperature of the extremities in 14 cases of Raynaud's disease and in 8 cases in which Raynaud's phenomenon was associated with such vascular diseases as acrosclerosis (3 cases), chronic occlusive disease of the arteries (3 cases), occupational disease of the arte...

Twelve out-patients with established angina pectoris who had previously participated in a double-blind trial of prenylamine lactate continued to record their daily anginal attack rate and glyceryl trinitrate consumption over the subsequent 18 months. The improvement noted while taking prenylamine during the trial was maintained and a further double-blind study confirmed that this was, in fact, ...