Background & Objective: Soft tissue sarcomas (STS) constitute an uncommon and heterogeneous group of tumors of mesenchymal origin and various cytogenetic abnormalities ranging from distinct genomic rearrangements, such as chromosomal translocations and amplifications, to more intricate rearrangements involving multiple chromosomes. Fluorescence in situ...

chemical technique. In this study, it appeared that the amount of immunohistochemically detectable RIG-I was related to the severity of the glomerular lesions, such as that of leucocyte exudation into the glomeruli, in the specimens obtained from cases with active lupus nephritis. Two cases, with severe histological changes and a very high histological activity index, showed significantly more ...

The targeted treatment of advanced non-small-cell lung cancer (NSCLC) depends on confirmation of activating somatic EGFR mutation. The aim of the study was to evaluate the incidence of EGFR mutations in NSCLC detected in cytological and histological material and present literature review on European EGFR mutation incidence. 273 patients with confirmed NSCLC were entered into the study: 189 hist...

The aim of this study was to show the technique and the methodological approach used in describing histological characteristics of induced periodontal disease in rats. To reach that inflammatory process, periodontal disease was induced by ligature, with or without sucrose-rich diet. Twenty-four female adult (60 days old) Wistar rats were divided in four groups: Group 1, or control (which receiv...

BACKGROUND The first-line treatment for resectable pancreatic cancer (RPC) is surgical resection. However, our patients have often experienced early recurrence after curative resection for RPC, with desperately poor prognosis. Some reports indicated that minimally distant metastasis not detected at operation might cause early recurrence. The present study aimed to identify preoperative clinicop...

background : invasive ductal carcinoma is one of the most common type of tumors in females, constituting a single large group of breast cancers. there are various prognostic factors, of which tumor grade, size and axillary lymph node metastasis are among the important ones. fine needle aspiration cytology is a commonly used diagnostic technique in the initial evaluation of breast lumps. in the ...

background: helicobacter pylori, which is associated with many upper gastrointestinal diseases, is found in half of the population of the world. several special stains and immunohistochemistry stain for h. pylori are available. the need for and usefulness of immunohistochemical (ihc) technique has been debated for years. toluidine blue is a simple stain for microbiological studies and is easily...

Nodular basal cell carcinoma, especially when pigmented, can be in differential diagnosis with nodular melanomas, clinically and dermoscopically. Reflectance confocal microscopy is a relatively new imaging technique that permits to evaluate in vivo skin tumors with a nearly histological resolution. Here, we present four cases of challenging nodular lesions where confocal microscopy was able to ...

BACKGROUND The fibrous structure of the myometrium has previously been characterised at high resolutions in small tissue samples (< 100 mm3) and at low resolutions (∼500 μm per voxel edge) in whole-organ reconstructions. However, no high-resolution visualisation of the myometrium at the organ level has previously been attained. METHODS AND RESULTS We have developed a technique to reconstruct ...