BACKGROUND Against a background of interest in rates of diabetes in schizophrenia and related psychoses and claims that data from historical periods demonstrate a link that antedates modern antipsychotics, we sought to establish the rate of diabetes in first onset psychosis and subsequent prevalence in historical and contemporary cohorts. METHODS Analysis of two epidemiologically complete dat...

In this paper we present an efficient segmentation-free word spotting method, applied in the context of historical document collections, that follows the query-byexample paradigm. We use a patch-based framework where local patches are described by a bag-of-visual-words model powered by SIFT descriptors. By projecting the patch descriptors to a topic space with the Latent Semantic Analysis techn...

Sequence mismatch analysis (MMA) and Bayesian skyline plots (BSP) are commonly used to reconstruct historical demography. A survey of 173 research articles (2009-2014), which included estimates of historical population sizes from mtDNA or cpDNA, shows a widespread genetic signature of demographic or spatial population expansion in species of all major taxonomic groups. Associating these expansi...

This paper will demonstrate how new technologies in cartographic environment integrate acquisition, management and representation techniques for georefencing data processing. Moreover, there is an ever-growing demand for a more “representative” and “world widespread” digital cartography. More representative means the capabilities in describing physical phenomena but also social, economic and cu...

This paper presents a generic and systematic methodology for the generation of sustainable process alternatives with respect to new process design as well as retrofit design. The generated process alternatives are evaluated through sustainability metrics, environmental impact factors as well as inherent safety indices. The process alternatives for new process design as well as retrofit design a...

Market risk exposure plays a key role for financial institutions risk management. A possible measure for this exposure is to evaluate losses likely to incur when the price of the portfolio’s assets declines using Value-at-Risk (VaR) estimates, one of the most prominent measure of financial downside market risk. This paper suggests an evolving possibilistic fuzzy modeling approach for VaR estima...

The David restoration project (started in Florence in 2002) has given several guidelines to the definition and development of innovative solutions to process and visualize 3D data in the framework of Cultural Heritage (CH) applications. Our main goal has been to demonstrate the usefulness of digital 3D models and of visualization tools in the framework of a restoration project. 3D models have b...

PURPOSE The purpose of this research was to compare the survival of patients with Philadelphia chromosome (Ph) -positive chronic myelogenous leukemia (CML) post-IFN-alpha failure treated with imatinib to historical experiences with standards of care or other therapies. EXPERIMENTAL DESIGN The outcome of 261 patients with Ph-positive chronic phase CML post-IFN failure treated with imatinib was...