Nitric oxide synthase (NOS) catalyzes the production of nitric oxide from L-arginine and dioxygen at a thiolate-ligated heme active site. Although many of the reaction intermediates are as yet unidentified, it is well established that the catalytic cycle begins with substrate binding and rate-limiting electron transfer to the heme. Here we show that Ru(II)-diimine and Re(I)-diimine electron tun...

Evidence from observational studies as well as prospective randomized trials indicates that the incidence of coronary artery disease is less in premenopausal women compared with age-matched men and in postmenopausal women who are using estrogen replacement therapy.1,2 The mechanisms by which estrogen reduces development of cardiovascular disease are multifactorial and, in addition to alteration...

For a system of an M-level atom interacting with cavity fields, the statistical properties of the field are investigated numerically. The variation of photon antibunching and probability distribution with the atomic level number and initial field intensity are discussed for both resonance and off-resonance cases. Accestcn For I I 7M I By1988 PACS Nos.: 32.80.-t, 42.50.-p, 42.50.Dv .... AvailabI...

OBJECTIVE The role of nitric oxide (NO) in myocardial ischemia/reperfusion injury remains controversial as both NO donors and NO synthase (NOS) inhibitors have shown to be protective. We generated transgenic (TG) mice that overexpress endothelial NOS (eNOS) exclusively in cardiac myocytes to determine the effects of high cardiac NO levels on ischemia/reperfusion injury and cellular Ca(2+) homeo...

INTRODUCTION The aim of this study was to evaluate whether the index of orthodontic treatment need (IOTN) could be weighted by using consumer-based sociodental measures to predict the uptake of orthodontic services. METHODS The sample consisted of 525 schoolchildren, 11 to 12 years old, from Greater Manchester, United Kingdom. Child-perceived IOTN aesthetic component (AC), examiner IOTN AC an...

Nitric oxide has been shown to have important physiological regulatory roles, i. e, vasodilation, neurotransmitter release, etc. Now, we review its role as an antibacterial and antiviral agent. Nitric oxide has also been identified as an important factor in the development of non-specific immunity. And accordingly, nitric oxide synthase (NOS), the catalytic enzyme producing nitric oxide, is a k...

* To whom correspondence should be addrcsscd. Step 2・ . To 61 of homogenate, DEAE-cel]ulose (600g, wet wci.oht) pre-equilibruted with 10mM sodium acctate buffer (pH 6,O) was added and thc suspension was stirred gent]y at O"C fbr 3emin, The DEAE-cellu]ose-udsorbcd protein was coilected by suction and washed with 3 1 of thc same bufi'er. then suspendcd in the same buffcr. The column packcd -・ith ...

The aim of this study was to investigate the role of nitric oxide (NO) in hepatic ischemia-reperfusion (I/R) injury in rats. Immunohistochemistry was used to examine the protein expression of endothelial and inducible nitric oxide synthases (eNOS, iNOS) and nitrotyrosine after I/R challenges to the liver, and blood levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lact...

The relationship between nitric oxide (NO) synthase II (NOS II) expression and the metastatic ability of tumor cells is inconclusive. We determined the role of host NOS II expression in the growth and metastasis of the B16-BL6 murine melanoma and M5076 murine ovarian sarcoma cell lines. The cells were either s.c. or i.v. injected into syngeneic wild-type (NOS II) and NOS II-null (NOS II) C57BL/...