نتایج جستجو برای: i nos

تعداد نتایج: 1094087  

ژورنال: :فصلنامه دامپزشکی و آزمایشگاه 0
عباس جواهری وایقان1 ، محمد جواد قراگزلو2 رضا نیکبخت بروجنی2 ، جمیله سالار آملی2 ، کبری کیخسروی3

مقدمه و هدف : کادمیوم(cd) با عدد اتمی 48 و وزن اتمی41/112 یکی از عناصر کمیاب ولی گسترده در سراسر جهان است. به دلیل افزایش ورود کادمیوم به بدن موجودات زنده از طرق مختلف و افزایش احتمال مسمومیت با آن این موضوع در دستور کار سازمان بهداشت جهانی(who )قرار گرفته است.   کادمیوم می تواند جای روی را در پروتئین ها و آنزیم های بدن بگیرد و نیز به عنوان یک کاتیون و یا با اتصال به مولکول های رسوب دهنده ای از...

Journal: :American journal of physiology. Renal physiology 2004
Scott C Thomson Aihua Deng Norikuni Komine John S Hammes Roland C Blantz Francis B Gabbai

Dysregulation of kidney nitric oxide synthase (NOS) I may alter renal hemodynamics in diabetes. Four types of studies were performed in anesthetized 1- to 2-wk-streptozotocin diabetic rats. 1) Glomerular filtration rate (GFR) was measured before and during NOS I blockade. Subsequent addition of nonspecific NOS blocker tested for residual NO from other isoforms. Acute systemic NOS I blockade red...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 1999
P M Schwarz H Kleinert U Förstermann

Skeletal muscle and myocardium express microNOS I, an elongated splice variant of neuronal-type nitric oxide (NO) synthase (NOS I), and NOS III, endothelial-type NO synthase, respectively. This study was designed to elucidate whether vascular smooth muscle also contains a constitutively expressed NO synthase isoform. In the rat, microNOS I contains an insert of 102 nucleotides after nucleotide ...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995
P Ogilvie K Schilling M L Billingsley H H Schmidt

In the adult central nervous system, nitric oxide (NO) is formed from L-arginine by the so-called constitutive or type I NO synthase (NOS-I155). However, expression of NOS-I155 immunoreactivity and activity was low or not detectable in developing mouse and rat brain. NOS-I155 was sharply induced coincident with the onset of synaptogenesis in specific brain regions. This was followed by a second...

2013
Christopher Bond Omer Onur Cakir Kevin T. McVary Carol A. Podlasek

INTRODUCTION Neuronal nitric oxide synthase (NOS-I) is significantly decreased with Cavernous Nerve (CN) injury in Erectile Dysfunction (ED) models. Increased apoptosis and collagen deposition accompany decreased NOS/CN injury, however these changes are typically attributed to the altered signaling of other factors, and a contribution of NOS in maintenance of urogenital structures has not previ...

رضا نیکبخت بروجنی2 ، جمیله سالار آملی2 ، کبری کیخسروی3 عباس جواهری وایقان*1 ، محمد جواد قراگزلو2

 مقدمه و هدف : کادمیوم(Cd) با عدد اتمی 48 و وزن اتمی41/112 یکی از عناصر کمیاب ولی گسترده در سراسر جهان است. به دلیل افزایش ورود کادمیوم به بدن موجودات زنده از طرق مختلف و افزایش احتمال مسمومیت با آن این موضوع در دستور کار سازمان بهداشت جهانی(WHO )قرار گرفته است.   کادمیوم می تواند جای روی را در پروتئین ها و آنزیم های بدن بگیرد و نیز به عنوان یک کاتیون و یا با اتصال به مولکول های رسوب دهنده...

Journal: :The Journal of pharmacology and experimental therapeutics 2002
John Weaver Supatra Porasuphatana Pei Tsai Guan-Liang Cao Theodore A Budzichowski Linda J Roman Gerald M Rosen

Nitric-oxide synthase (NOS; EC 1.14.13.39) catalyzes the oxidation of L-arginine to nitric oxide (NO(.)) and L-citrulline via the intermediate N(omega)-hydroxy-L-arginine. Of the three distinct isoforms of NOS that have been characterized, the constitutive neuronal NOS (NOS I) generates NO(.) associated with long-term potentiation (LTP) and early brain development. All of the NOS isoforms conta...

Journal: :Molecular and cellular neurosciences 2007
Sabrina Fritzen Angelika Schmitt Katharina Köth Claudia Sommer Klaus-Peter Lesch Andreas Reif

Investigations regarding the regulation of adult neurogenesis, i.e., the generation of new neurons from progenitor cells, have revealed a high degree of complexity. Although the pleiotropic messenger molecule nitric oxide (NO) has been suggested to modulate adult neurogenesis, the evidence is inconclusive due to the presence of different NO synthase isoforms in the brain. We therefore investiga...

Journal: :Molecular pharmacology 1998
P M Schwarz B Gierten J P Boissel U Förstermann

Neuronal-type nitric oxide synthase (NOS I) is involved in ischemia-induced brain damage, and glucocorticoids have been reported to protect from brain damage. This prompted us to investigate if the activity or expression of NOS I was influenced by glucocorticoids. We used the murine neuroblastoma cell line N1E-115 as our experimental model. Short-term incubation (30 min) of the N1E-115 cells wi...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
N Klöcker P Kermer M Gleichmann M Weller M Bähr

Although neurotrophins are best known for their trophic functions, growing evidence suggests that neurotrophins can also be neurotoxic, for instance by enhancing excitotoxic insults. We have shown recently that brain-derived neurotrophic factor (BDNF) limits its neuroprotective action on axotomized rat retinal ganglion cells (RGCs) by upregulating nitric oxide synthase (NOS) activity (Klöcker e...

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