Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including development, reproduction, longevity and several specific stress responses. Our systematic studies identify an ILP-based combinatorial code for these phe...

Ill [6] Albert Visser shows that ILP completely axiomatizes all schemata about provabihty and relative interpretability that are prov-able in finitely axiomatized theories. In this paper we introduce a system called ILP ~ that completely axiomatizes the arithmetically valid principles of provability in and interpretabihty over such theories. To prove the arith-metical completeness of ILP ~ we u...

This paper addresses the problem of test pattern generation for single stuck-at faults in combinational circuits, under the additional constraint that the number of specified primary input assignments is minimized. This problem has different applications in testing, including the identification of don’t care conditions to be used in the synthesis of Built-In SelfTest (BIST) logic. The proposed ...

The language-based theory of regions, stemming from the area of Petri net synthesis, forms a fundamental basis for Integer Linear Programming (ILP)-based process discovery. Based on example behavior in an event log, a process model is derived that aims to describe the observed behavior. Building on top of the existing ILP-formulation, we present a new ILP-based process discovery formulation tha...

This paper summarizes the current state of the art in the topics of rst-order theory revision and theory restructuring. The various tasks involved in rst-order theory reenement (revision vs. restructuring) are deened and then discussed in turn. For theory revision, the issue of minimality is discussed in detail, and a general outline algorithm is given which identiies the major places of diiere...

Have state-of-the-art clinical trials failed to deliver treatments for neurodegenerative diseases because of shortcomings in the rating scales used? This Review assesses two methodological limitations of rating scales that might help to answer this question. First, the numbers generated by most rating scales do not satisfy the criteria for rigorous measurements. Second, we do not really know wh...

Modern superscalar and VLIW processors fetch, decode, issue, execute, and retire multiple instructions per cycle. By taking advantage of instruction-level parallelism (ILP), processor performance can be improved substantially. However, increasing the level of ILP may eventually result in diminishing and negative returns due to control and data dependencies among subsequent instructions as well ...

Modern single-CPU microprocessors exploit instruction-level parallelism (ILP) by deriving their performance advantage mainly from parallel execution of ALU and memory instructions within a single clock cycle. This performance advantage obtained by exploiting data ILP is severely offset by sequential execution of conditional branches, especially in branch-intensive non-numerical code. Consequent...