Transcription is a stochastic process occurring mostly in episodic bursts. Although the local chromatin environment is known to influence the bursting behavior on long timescales, the impact of transcription factors (TFs)--especially in rapidly inducible systems--is largely unknown. Using fluorescence in situ hybridization and computational models, we quantified the transcriptional activity of ...

Mouse embryonic stem cells (mESCs) are self-renewing and capable of differentiating into any of the three germ layers. An interesting feature of mESCs is the presence of cell-to-cell heterogeneity in gene expression that may be responsible for cell fate decisions. Nanog, a key transcription factor for pluripotency, displays heterogeneous expression in mESCs, via mechanisms that are not fully un...

in studying of the in situ gravitational concentration process part feature for placer, the technological ability to transform the in situ massif placer structure is evident. the two main processes involved in altering the massif in situ have been examined and outlined in detail. the in situ disintegration of massif material results in a new massif gravitational stratification structure. regula...

Persulfate-based in situ chemical oxidation (ISCO) has been increasingly used for the remediation of contaminated groundwater and soil. In recent years, there have numerous studies literature on all aspects activation persulfate contaminant removal at laboratory scale, including ways mechanisms activation, pathways degradation, factors associated with performance, methods characterizing process...

...................................................................................................................................................3 Introduction.............................................................................................................................................4 Fig. 1 The Functional Anatomy of Striatal Medium Spiny Neurons ......

Induction of Fas-mediated activation-induced cell death in antitumor T cells has been hypothesized to permit tumor escape from immune destruction. Several laboratories have proposed that expression of Fas ligand (L) by tumor is the basis for this form of T cell tolerance. In this study, we characterized murine tumor-infiltrating lymphocytes (TIL) for activation status, cell cycle status, level ...

abstractvarious nanoparticles have been investigated as novel drug delivery systems, including solid lipid nanoparticles (slns). due to their rapid clearance from systemic circulation, nanoparticles do not provide sustained action in most cases. different strategies have been employed to overcome this problem. in this direction, the present study introduces erodible in-situ forming gel systems ...