Audiometric changes following quinine administration were studied in healthy Caucasian subjects and patients suffering from falciparum malaria disease. Quinine-dihydrochloride was administered intravenously as a single dose of 300 mg to 12 healthy subjects and as multiple doses of 600 mg in 4 h every 8 h in 10 Plasmodium falciparum malaria patients. The hearing function was monitored by convent...

Objective: Malaria is an infectious disease commonplace in tropical countries. For many years, major antimalarial drugs consisted of natural products, but since 1930s these drugs have been largely replaced with a series of synthetic drugs. This article tries to briefly indicate that some plants which previously were used to treat malaria, as a result of deficiencies of synthetic drugs, have rev...

Evidence has been presented which indicates that antibodies appear in the serum of individuals following an induced malaria infection with Plasmodium knowlesi.

Paludrine, N1-p-chlorphenyl-N5-isopropylbiguanide acetate, was found by British workers to be ;he most active antimalarial of a series of synthetic guanidines and biguanidines (1, 2). It possesses high activity against the erythrocytic asexual parasites of both vivax and falciparum malaria and is practically non-toxic at therapeutic doses (3, 4). Previous study of the compound has included exte...

the treatment given to the mad chauffeur. Repeated rigors were induced by deliberately giving the wretched man malaria. When the consultant physician decided enough was enough, the malaria was treated with quinine sulphate. Sometime later I learnt of the rationale for this useless treatment. In the First World War, a German Army doctor stationed in Albania had noted that in that country where s...

Preventing and treating malaria in pregnancy is a global health priority. However little is known regarding the impact of malaria infection on the maternal and fetal disposition of pharmaceuticals and other xenobiotics. Our objective was to characterize expression of key determinants of drug-disposition in maternal and fetal tissues in a validated murine model of experimental placental malaria....

Rapidly emerging insecticide resistance is creating an urgent need for new active ingredients to control the adult mosquitoes that vector malaria. Biopesticides based on the spores of entomopathogenic fungi have shown considerable promise by causing very substantial mortality within 7-14 days of exposure. This mortality will generate excellent malaria control if there is a high likelihood that ...

BACKGROUND & OBJECTIVES Paramilitary operations along the Indo-Bangladesh border are adversely affected by malaria induced morbidity and mortality. Villages surrounding the paramilitary installations often serve as disease reservoirs. Malaria incidence in Tripura State Rifles (TSR) units in Dhalai District of Tripura was studied and the role of the village population in disease transmission was...