Interleukin-32 (IL-32) is a pro-inflammatory cytokine that induces other cytokines involved in inflammation, including tumour necrosis factor (TNF)-?, IL-6 and IL-1?. Recent evidence suggests IL-32 has crucial role host defence against pathogens, as well the pathogenesis of chronic inflammation. Abnormal expression been linked to several autoimmune diseases, such rheumatoid arthritis inflammato...

Alzheimer, a chronic neurodegenerative disease, usually starts slowly and worsens gradually. It causes 60% to 70% of dementia cases. Difficulty in remembering recent events (short-term memory loss) is the most prominent early symptom. As the disease progresses, patients may have problems such as impaired language, disorientation (including easily getting lost), mood swings, loss of motivation, ...

The global obesity epidemic is contributing to increased prevalence of diseases fuelled by chronic inflammation, including cancer. Oesophageal adenocarcinoma (OAC) an obesity-associated malignancy with increasing prevalence, dismal prognosis, and severely dysregulated immune processes. We previously reported that αβ T cells migrate omentum liver in OAC contribute inflammation these tissues. Her...

Alpha-1-proteinase inhibitor (API) is one of the acute phase proteins. Following an inflammatory stimuli the concentration of API increased up to four folds. Accompanying these quantitative changes, there is qualitative alterations in the structure of carbohydrate moiety (glycosylation). To determine the alterations in the glycosylation of API in inflammation, API was isolated from the sera of...

Inflammation is one of the major health threats to humans, and it associated with various chronic diseases, including metabolic syndrome, type 2 diabetes, cardiovascular several types cancer. For example, colonic inflammation can result in damage intestinal barrier, as indicated by invasion immune cells reduced tight junctions. Inflammatory responses also lead erythema edema on skin. The interv...

The results of studies the level biomarkers oxidative stress and antioxidant system in children with Crohn’s disease ulcerative colitis are presented. relationship between nosology feature redox imbalance was demonstrated, which proved by a significant difference reduced glutathione erythrocytes groups subjects. Children have lower erythrocyte compared to patients colitis. This pattern can be e...

The non-systematic literature review describes the mechanisms by which breastfeeding prevents development of metabolic syndrome and socially significant diseases associated with it: obesity, diabetes type 2 atopic diseases. One programming is effect breast milk on infant's intestinal microbiota. Human oligosaccharides can stimulate growth commensal bacteria. Cytokines, secretory immunoglobulins...

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the regulation genes involved in inflammation and immune responses. NF-κB may play an important role cardiovascular diseases (CVDs), atherosclerosis diabetes. Several therapeutic agents used treatment CVDs diabetes, such as pimobendan sodium–glucose cotransporter 2 inhibitors, exert anti-inflammatory effec...

Abstract The challenge to improve human life span has progressed with the advent of health care services and technologies. This improvement poses a new an associated wave diseases pathologies that have not been observed or experienced. led rise in geriatric population who are currently facing challenges needs be addressed by research community. review focuses primarily on two mechanisms contrib...