By introducing lattice-valued covers of a set, we present a general framework for uniform structures on very general L-valued spaces (for L an integral commutative quantale). By showing, via an intermediate L-valued structure of uniformity, how filters of covers may describe the uniform operators of Hutton, we prove that, when restricted to Girard quantales, this general framework captures Hutt...

For the purpose of testing the spherical uniformity based on i.i.d. directional data (unit vectors) zi, i = 1, . . . , n, Anderson and Stephens (1972) proposed testing procedures based on the statistics Smax = maxu S(u) and Smin = minu S(u), where u is a unit vector and nS(u) is the sum of square of u′zi’s. In this paper we also consider another test statistic Srange = Smax − Smin. We provide f...

In cite{Kats84}, Katsaras introduced a method for constructing a Hu-tton $[0,1]$-quasi-uniformity from a crisp uniformity. In this paper we present other different methods for making this based mainly in the concept of a fuzzy uniform structure. Furthermore, we prove that some of these methods preserve the completeness property of the quasi-uniformity.  Moreover, we also show that Katsaras' con...

Serum human chorionic gonadotrophin (HCG) concentrations were determined by radioimmunoassay with an antiserum specific to HCG beta-subunit in 42 patients with hyperemesis gravidarum and 115 women with normal pregnancies. Mean concentrations (+/- SE of mean) were higher in the women with hyperemesis gravidarum at 7-8 weeks (40.8 +/- 5.2 IU/ml v 22.1 +/- 1.4 IU/ml; P less than 0.001), 9-11 weeks...

A recombinant fusion protein linking coagulation factor IX (FIX) with human albumin (rIX-FP) has been developed to facilitate hemophilia B treatment by less frequent FIX dosing. This first-in-human dose-escalation trial in 25 previously treated subjects with hemophilia B (FIX ≤ 2 IU/dL) examined the safety and pharmacokinetics of 25, 50, and 75 IU/kg rIX-FP. Patients in the 50-IU/kg cohort unde...

Intolerance of uncertainty (IU) has been proposed to be an important maintaining factor in several anxiety disorders, including generalized anxiety disorder, obsessive-compulsive disorder, and social phobia. While IU has been shown to predict subjective ratings and decision-making during uncertain/ambiguous situations, few studies have examined whether IU also predicts emotional responding to u...

Purported genetic associations found in population studies require validation for confirmation. We previously reported rubella vaccine-induced immune responses and HLA associations in 346 adolescents, age 12-18 years (1st cohort), following two doses of a rubella-containing vaccine. We sought to replicate the associations discovered in that work by verifying these associations in a new cohort o...