background: recent researches have led to find strategies to prevent relapse and to improve survival for gastric cancer patients, including preoperative neo-adjuvant approaches. however, the efficacy of some neo-adjuvant regimens including 5-fluorouracil, cisplatin, and docetaxel have been less investigated. the present study evaluated the outcome and mid-term survival of patients with gastric ...

introduction: chemotherapeutic drugs used to treat cancer may cause nausea and emesis by inducing the release of 5-hydroxytryptamine (5-ht) in the small intestine. blockage of 5-ht 3 receptors in the small intestine by 5-ht 3 receptor antagonists might prevent the nausea and vomiting associated with chemotherapy for cancer. the aim of this study was to compare the efficacy and tolerability of t...

BACKGROUND Several systematic reviews suggest that intermittent pulmonary tuberculosis (TB) chemotherapy is effective, but intensity (daily versus intermittent) and duration of rifampicin use (intensive phase only versus both phases) have not been distinguished. In addition, the various outcomes (success, failure, relapse, and default) have only selectively been evaluated. METHODS We conducte...

Immunomodulating monoclonal antibodies (mAb) can evoke antitumor T-cell responses, which are attenuated by regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC). Treatment with cyclophosphamide (CP) and gemcitabine (GEM) can mitigate the immunosuppression by Treg and MDSC, respectively. In the current study, we examined the antitumor effects of a combination of local injection w...

OBJECTIVE This work summarizes the clinical features and treatment of 10 AIDS patients with malignant lymphoma. METHODS A total of 10 AIDS patients with malignant lymphoma seen in Beijing Ditan Hospital since 2009 were enrolled. Clinical manifestations, pathological examinations, immunity levels, Epstein-Barr virus antibody examinations, complications, treatments, and outcomes were retrospect...

Introduction: Physical activity and obesity affect the release of effective adipokines. In this regard, the present study investigated the effects of intermittent and continuous exercise in water and land (running on a treadmill) on visfatin, insulin, and blood glucose in pre and post menopausal obese women. Methods: In this quasi-experimental study, 18 obese women of Bandar Abbas City were ...

radiotherapy in the head and neck region and chemotherapy might give rise to oral mucositis which is a severe and painful inflammation. there is no known definite cure for mucositis. a number of studies have attempted to evaluate the effect of low-power laser on radiotherapy- and chemotherapy-induced mucositis. the present study was undertaken to evaluate the effect of low-power laser on the pr...

Drug resistance leads to chemotherapy failure and is responsible for the death of a great majority of patients withmetastatic, late-stage ovarian cancer. The present study addressedwhether changes in the chemotherapy dosing schedule affect the development, further worsening, or circumvention of drug resistance in chemosensitive and chemoresistant ovarian cancer. Severe combined immunodeficient ...