نتایج جستجو برای: intermittent chemotherapy

تعداد نتایج: 149384  

Journal: :international journal of hematology-oncology and stem cell research 0
mozaffar aznab imam reza hospital and taleghani hospital, kermanshah university of medical sciences, kermanshah, iran bahram samadzadeh imam reza hospital, kermanshah university of medical sciences, kermanshah, iran assad moradi imam reza hospital, kermanshah university of medical sciences, kermanshah, iran abdol rosol bardideh imam reza hospital, kermanshah university of medical sciences, kermanshah, iran jamal hoseini clinical research developemental center, kermanshah university of medical sciences, kermanshah, iran kazhal kaviani moghadam statistic department, private statistic institute, kermanshah, iran

introduction: prostate cancer is one of the most common cancers among males and the second factor resulting to death due to cancer among them.(1) the median age of its diagnosis is 65 years. the initial treatment includes androgen ablation or orchiectomy.(2, 3) in case of patient’s hormone refractory, chemotherapy would be substituted. the objective of this study is the consideration of intermi...

Journal: :basic and clinical cancer research 0
fariba behnamfar associate professor, department of obstetrics and gynecology, school of medicine, isfahan university of medical sciences, isfahan, iran fereshteh mohammadizadeh associate professor, department of pathology, school of medicine, isfahan university of medical sciences, isfahan, iran leila hashemi resident of obstetrics and gynecology, school of medicine, isfahan university of medical sciences, isfahan, iran somayeh sheikhalian resident of obstetrics and gynecology, school of medicine, isfahan university of medical sciences, isfahan, iran

gestational choriocarcinoma usually occurs following an intrauterine pregnancy. we report a case of metastatic choriocarcinoma to the left kidney and lungs with long term intermittent amenorrhea and vaginal bleeding after a normal vaginal delivery. a 43 year old rural woman presented with three years intermittent amenorrhea and vaginal bleeding following normal vaginal delivery. she also compla...

2014
Harpreet Wasan Angela M Meade Richard Adams Richard Wilson Cheryl Pugh David Fisher Benjamin Sydes Ayman Madi Bruce Sizer Charles Lowdell Gary Middleton Rachel Butler Richard Kaplan Tim Maughan

BACKGROUND Advanced colorectal cancer is treated with a combination of cytotoxic drugs and targeted treatments. However, how best to minimise the time spent taking cytotoxic drugs and whether molecular selection can refine this further is unknown. The primary aim of this study was to establish how cetuximab might be safely and effectively added to intermittent chemotherapy. METHODS COIN-B was...

2011
Richard A Adams Angela M Meade Matthew T Seymour Richard H Wilson Ayman Madi David Fisher Sarah L Kenny Edward Kay Elizabeth Hodgkinson Malcolm Pope Penny Rogers Harpreet Wasan Stephen Falk Simon Gollins Tamas Hickish Eric M Bessell David Propper M John Kennedy Richard Kaplan Timothy S Maughan

BACKGROUND When cure is impossible, cancer treatment should focus on both length and quality of life. Maximisation of time without toxic effects could be one effective strategy to achieve both of these goals. The COIN trial assessed preplanned treatment holidays in advanced colorectal cancer to achieve this aim. METHODS COIN was a randomised controlled trial in patients with previously untrea...

Journal: :Molecular cancer therapeutics 2010
Raquel De Souza Payam Zahedi Eduardo H Moriyama Christine J Allen Brian C Wilson Micheline Piquette-Miller

Ovarian cancer is known as the silent killer for being asymptomatic until late stages. Current first-line treatment consists of debulking surgery followed by i.v. chemotherapeutics administered intermittently, which leads to insufficient drug concentrations at tumor sites, accelerated tumor proliferation rates, and drug resistance, resulting in an overall median survival of only 2 to 4 years. F...

2010
Shuichi YANO Kanako KOBAYASHI Toshikazu IKEDA Yoshiyuki TOKUDA Kiryo WAKABAYASHI Shigenori ISHIKAWA Hiroyasu TAKEYAMA Shuichi Yano

Objective] To evaluate the relapse rate after treatment of a twice weekly intermittent chemotherapy during continuation phase in the patients with pulmonary tuberculosis in two years poriod after completion of chemotherapy. [Methods] The patients with drug susceptible pulmonary tuberculosis treated with 2HRZE/4H2R2 under the supervision by the pharmacists or the patients treated with 2HRZE/4HR ...

Journal: :Molecular cancer therapeutics 2008
Vessela Vassileva Christine J Allen Micheline Piquette-Miller

Tumor repopulation between cycles of chemotherapy likely has a negative effect on clinical outcome in ovarian cancer patients. Thus, avoiding treatment-free periods when tumor cells proliferate by providing sustained chemotherapy regimens may improve clinical response. We investigated the effect of sustained versus intermittent paclitaxel administration on tumor repopulation in ovarian cancer. ...

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