Identifying the ‘right’ dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated safety problems, while choosing too low a dose leads to smaller chances of showing sufficient efficacy in confirmatory trials, thus reducing the c...

background: gel polymers are considered as new dosimeters for determining radiotherapy dose distribution in three dimensions. objective: the ability of a new formulation of magic-f polymer gel was assessed by experimental measurement and monte carlo (mc) method for studying the effect of gold nanoparticles (gnps) in prostate dose distributions under the internal ir-192 and external 18mv radioth...

Dry powder inhalers (DPIs), opposed to the traditional pre-metered dose inhalers (MDIs), prove to be more advantageous in delivering the desired dosage of medication to the targeted site. Now, engineers are designing better DPIs and new carrier particles that have better characteristics for drug delivery.

Radiosurgery or stereotactic radiosurgery was invented by Swedish neurosurgeon Lars Leksell in 1951. defined as “delivery of a single, high dose irradiation to small and critically located intracranial volume through the intact skull.” His initial efforts were focused on developing noninvasive method create lesions within brain, using radiation rather than conventional blade. In 1968, first Gam...

Background: The same conversion factors (k-factors) of Single CT (SECT) are applied to estimate the Effective Dose (ED) in Dual Energy Computed Tomography (DECT). However, k-factors for different organs need independently validating DECT, due conditions DECT. Objective: This study aimed calculate organ dose and imaging protocols (liver, chest, cardiac, abdomen) male female phantoms. Material Me...

Radioiodine therapy is known as the most effective treatment of differentiated thyroid carcinoma (DTC) to ablate remnant thyroid tissue after surgery. In patients with DTC treated with radioiodine, internal radiation dosimetry of radioiodine is useful for radiation risk assessment. The aim of this study is to describe a method to estimate the absorbed dose to the blood using medical internal ra...