UNLABELLED Quantitative small-animal PET of mice requires successful delivery of radiotracers into the venous system. Intravenous injection of radiotracers via lateral tail veins is the most commonly used method of administration and can be technically challenging. Evaluation of the quality of an intravenous injection is necessary to determine whether small-animal PET is quantitatively accurate...

Functionally hepatectomized rabbits showed convulsions and coma within 2 hours after the intravenous injection of fat emulsion and heparin. Intravenous injection of the detergent triton prevented this syndrome, if given before the fat emulsion and heparin, and reversed it if given subsequently. Extremely high plasma non-esterified fatty acid levels were noted in rabbits showing the convulsive s...

The occurrence of toxic reactions following the use of topically applied local anaesthetics continues to be reported intermittently in the medical literature. Most of the reactions reported are convulsive in nature and many non-fatal cases have been treated by the intravenous injection of barbiturates, inhalation of oxygen, or oxygen and carbon dioxide mixtures, and other measures. The followin...

The toxic effects of intraperitoneal, intrauterine and intravenous administration of quinacrine hydrochloride solution were evaluated in female adult rhesus monkeys (Macaca mulatta). A single intraperitoneal injection of 400 mg and above resulted in the development of toxic manifestations leading to death of monkeys. Intrauterine instillation of 500 mg of quinacrine was well tolerated and did n...

BACKGROUND Lower systemic toxicity reported with ropivacaine and levobupivacaine may produce less reliable recognition of inadvertent intravenous injection during regional anesthesia. This study was undertaken to determine whether ropivacaine and levobupivacaine are suitable for use as intravenous test doses by evaluating central nervous system (CNS) symptoms after intravenous bolus injection. ...

PURPOSE To investigate the effect of an intravenous infusion of carteolol on tissue blood flow in the optic nerve head (ONH) of rabbits. METHODS Rabbits received either a 3-week topical instillation, or a single intravenous injection (10, 20, 30 microg/kg) or a continuous intravenous injection (2.5, 5, 20, 40, 80 microg/kg per hour) of carteolol. The plasma carteolol level was determined by t...

Objective(s): Existing studies have demonstrated that intravenous and intramyocardial-administrated mesenchymal stem cells (MSCs) lead to tissue repair after cardiac disorders. We compared the efficiency of both administration methods.Materials and Methods: A rat model of isoproterenol-induced heart failure (ISO-HF) was established to co...

Rational: Shenmai injection is derived from traditional Chinese medicine Shenmai San (pulse-activating powder) with main active ingredient extracted from Radix ginseng Rubra and Radix Ophiopogonis. Ginsenoside Rg1 and Re are two major constituents of Radix ginseng Rubra considered responsible for the efficacy of this injection. In the present study, we carried out pharmacokinetics studies on Sh...

u minute3 in spite of my best efforts to rescue him. This was the first urea stibamine injection which the patient had received, and death might possibly have been due to over-sensitiveness (opinion of Dr. S. K. Sen, Civil Surgeon, Purnea). It will not be out of place to mention here that during the course of more than 20 years of hospital practice I have given not less than 20 to 30 thousand i...

Seeding and spread of beta-amyloid (Aβ) pathologies have been considered to be based on prion-like mechanisms. However, limited transmissibility of Aβ seeding activity upon peripheral exposure would represent a key difference to prions, not only in terms of pathogenesis but also in terms of potential transmission of disease. We partially characterized the seeded Aβ amyloidosis after intracerebr...