It is postulated that secreted soluble factors are important contributors of bystander effect and adaptive responses observed in low dose ionizing radiation. Using multidimensional liquid chromatography-mass spectrometry based proteomics, we quantified the changes of skin tissue secretome--the proteins secreted from a full thickness, reconstituted 3-dimensional skin tissue model 48 hr after exp...

A 64-year-old man, phototype V in Fitzpatrick scale, presented with a 5-year history of a slowly extending ulcer of the scalp. He had a past medical history of diabetes mellitus and ionizing radiation for tinea capitis in childhood. The physical examination revealed an oval-shaped ulcer measuring 7 cm in width x 5 cm in length, with a raised pigmented border; the center was alopecic, scattered ...

The roles of various core components, including α/β/γ-type small acid-soluble spore proteins (SASP), dipicolinic acid (DPA), core water content, and DNA repair by apurinic/apyrimidinic (AP) endonucleases or nonhomologous end joining (NHEJ), in Bacillus subtilis spore resistance to different types of ionizing radiation including X rays, protons, and high-energy charged iron ions have been studie...

Cosmic rays are known to cause biological effects directly and through ionizing radiation produced by their secondaries. These effects have been detected in airline crews and other specific cases where members of the population are exposed to above average secondary fluxes. Recent work has found a correlation between solar particle events and congenital malformations. In this work we use the re...

BACKGROUND Within the medical facilities provided by state healthcare services, a universally applied technique for patient diagnosis and treatment relies on ionising radiation; for example in radiotherapy and X-ray (ie. examination). Human exposure to such radiation is not however entirely free of associated health risks. OBJECTIVES To determine and estimate the numbers and types of X-ray ba...

Radionuclide myocardial perfusion imaging (MPI) using single photon emission computed tomography (SPECT) or positron emission tomography (PET) for the detection of ischemia in patients with known or suspected coronary artery disease (CAD) has widespread clinical utilization and has been shown to have high accuracy and incremental prognostic value. Amidst the recent publicity regarding the incre...

D ue to the increasing availability and recent advances in computed tomography (CT) technology, use of CT has increased. In 2007, approximately 68.7 million CT examinations were performed in the United States. In comparison, in 1995 approximately 21 million CT examinations were performed. Many investigators have expressed concern for the rising cumulative doses of ionizing radiation delivered t...

Ionizing radiation causes DNA damage and chromosome abbreviations on normal cells. The radioprotective effect of celecoxib (CLX) was investigated against genotoxicity induced by ionizing radiation in cultured human blood lymphocytes. Peripheral blood samples were collected from human volunteers and were incubated at different concentrations at 1, 5, 10 and 50 μM of CLX for two hours. At each do...

Tumor necrosis factor (TNF) production following X-irradiation has been implicated in the biological response to ionizing radiation. Protein kinase C (PKC) is suggested to participate in TNF transcriptional induction and X-ray-mediated gene expression. We therefore studied radiation-mediated TNF expression in HL-60 cells with diminished PKC activity produced by either pretreatment with protein ...