Epilepsy is a chronic neurological disease which is usually associated with psychiatric comorbidities. Depsression and cognition impairment are considered to be the most common psychiatric comorbidities in epilepsy patients. However, the specific contribution of epilepsy made to these psychiatric comorbidities remains largely unknown. Here we use pentylenetetrazole (PTZ) kindling, a chronic epi...

Kindling produces enduring neural changes that are subsequently manifest in enhanced susceptibility to seizure-evoking stimuli and alterations in some types of behavior. The present study investigated the effects of dorsal hippocampal (dHPC) kindling on a variety of behaviors to clarify the nature of previously reported effects on spatial task performance. Rats were kindled twice daily with dHP...

The current study examined whether stress reactivity becomes stronger or weaker with age. Daily stress and daily negative affect were modeled using 1,012 subjects from the National Study of Daily Events (NSDE), an 8-day daily diary study. Age ranged from 25 to 74. Data were modeled using within-person HLM techniques. Daily stress and neuroticism interacted in their effect on daily negative affe...

the role of opioid receptor and voltage dependent calcium channels on the kindling induced by the convulsant pentylenetetrazole (ptz) were investigated in the rats. experiment involved 24 rats which were divided into four groups. kindling was established with ptz in subconvulsive dose (37.5 mg/kg i.p.) every 48 h and effects were observed within 20 min using five-point scoring system. all anima...

introduction: the claustrum interconnects with the allocortical and neocortical regions and also projects to the hippocampus and the amygdala. .the role of claustrum in the complex partial seizure is not clear. thus in this study the effect of amygdala lesion on anterior claustrum kindled seizures in rat were investigated. methods: male wistar rats, weighting 250-300 g, were received dc current...

introduction: although hippocampus is the most famous brain area involved in temporal lobe epilepsy, hippocampal kindling (hk) develops very slowly. hence, rapid kindling is usually preferred to the traditional kindling and it is widely used. in this article we aimed at finding the optimal stimulus pattern, which yields the fastest hk rate. methods: stimulus patterns with different duration (2,...

OBJECTIVE Maternal immune activation (MIA) triggered by infections has been identified as a cause of autism in offspring. Considering the involvement of perturbations in innate immunity in epilepsy, we examined whether MIA represents a risk factor for epilepsy as well. The role of specific MIA components interleukin (IL)-6 and IL-1β was also addressed. METHODS MIA was induced in C57BL/6 mice ...

The ATP-gated P2X7 receptor (P2X7R) is a non-selective cation channel which senses high extracellular ATP concentrations and has been suggested as a target for the treatment of neuroinflammation and neurodegenerative diseases. The use of P2X7R antagonists may therefore be a viable approach for treating CNS pathologies, including epileptic disorders. Recent studies showed anticonvulsant potentia...