Sir, Of the different classes of carbapenemases, class B enzymes are clinically the most significant; they possess the widest substrate hydrolysis range, including penicillins, cephalosporins and carbapenems, but not monobactams. In recent years, metallo-b-lactamase (MBL) genes have spread from Pseudomonas aeruginosa to members of the Enterobacteriaceae. An alarming report by the HPA UK in 2009...

Background: Carbapenem-resistant Enterobacter (CRE) is an emerging threat spread rapidly around the world in past few years, posing substantial hazards to human health. Objective: The study was conducted evaluate prevalence of carbapenem resistance and detect carbapenemase producers phenotypically from patients a major tertiary care hospital, Bangladesh. Methods: Prospective cross-sectional Jul...

Pseudomonas aeruginosa is well known orthopedic wounds-associated bacterial pathogen, responsible for prolonged wound treatment, due to its resistance, mediated by different types of extended-spectrum beta-lactamases (ESBL). The present study was undertaken find the prevalence β lactamase (ESBL), Metallo-β (MBL), and AmpC in P. isolated from samples. Wound swabs were processed identified standa...

Carbapenem-resistant Acinetobacter baumannii has been considered one of the major threats to patients worldwide. To evaluate carbapenemase in several clinical isolates using phenotypic and genotypic approaches. A total 49 A. were tested against imipenem meropenem discs on Muller Hinton agar, then screened phenotypically through modified Hodge test (MHT), combined disc (CDT) carbapenem inactivat...

A case report of a multidrug-resistant (MDR) infection with a strain of Klebsiella pneumoniae carrying a novel metallo-b-lactamase (MBL), the New Delhi MBL (NDM-1), appears in this issue of Clinical Infectious Diseases [1]. Sidjabat and colleagues detail the presentation and susceptibility profile and give us a brief molecular characterization of an isolate of K. pneumoniae carrying blaNDM-1 th...

background metallo-beta-lactamase (mbl) producing pseudomonas aeruginosa in the burn patients is a leading cause of morbidity and mortality and remains a serious health concern among the clinicians. objectives the aim of this study was to detect mbl-producing p. aeruginosa in burn patients and determine multidrug-resistant (mdr) strains, and respective resistance patterns. patients and methods ...

Background & Aims: Imipenem is a member of Carbapenem with stability against most -lactamases .It is of particular use in the treatment of infections associated with drug resistant gram negative bacteria harboring ESBL and AmpC genes. The aim of this study was to determine the imipenem resistance in gram negative bacteria causing nosocomial infections and the presence of metallo--lactamases (MB...

BACKGROUND & OBJECTIVE Metallo beta-lactamase (MBL)-mediated resistance to carbapenems is an emerging threat in hospital isolates of Pseudomonas aeruginosa. Though there are several screening methods to detect this enzyme production, the National Committee for Clinical Laboratory Standards (NCCLS) does not have performance standards documented so far. There is not enough information from the In...

BACKGROUND Carbapenem-resistant Acinetobacter baumannii has emerged as an important cause of infection in burn patients. This study aimed to characterize the antimicrobial susceptibility pattern, determine the prevalence of oxacillinase and metallo-beta-lactamase (MBL) genes, and type the A. baumannii isolates obtained from burn patients. METHODS During a 1-year period, a total of 40 nondupli...